Want Better Skin But Do Not Want Toxic Skincare Ingredients? Want Clean Skincare That Actually Works And Is Backed By Research At The Cellular Level? Join Amitay Eshel on Biohackerblondie Podcast with Young Goose

This episode focuses on debunking common myths about skincare and introducing scientifically backed, biohacking skincare techniques.

1. The importance of understanding skincare ingredients and their effects at the cellular level.
2. Young Goose's commitment to clean, effective skincare backed by scientific research.
3. Insights into the benefits of NAD and red light therapy for skin health.
4. The role of lifestyle and daily habits in maintaining skin health.
5. The potential negative impacts of commonly used skincare treatments like radio frequency and microneedling without proper guidance.

1: Introduction to Young Goose

A brief overview of Young Goose's philosophy and products. Key discussion points include the importance of scientifically backed ingredients and the company's focus on effective, non-toxic skincare. Amitay Eshel: "Our mission is to provide products that not only promise to care for your skin but actually deliver results based on scientific research."

2: Deep Dive into Skincare Science

Discussion on the science behind effective skincare, including the use of NAD and red light therapy. Amitay Eshel: "We focus on the cellular level to ensure our skincare products truly benefit your skin's health."

3: Lifestyle and Skincare

Exploration of how lifestyle choices, such as diet and sleep, affect skin health. Jenny Jones: "It's not just about what you put on your skin, but also how you live your life that affects your skin health."

1. Evaluate skincare products based on the scientific backing of their ingredients.
2. Incorporate NAD-enhancing products into your skincare routine for better cellular health.
3. Use red light therapy to support skin rejuvenation.
4. Monitor your lifestyle habits, like sleep and diet, to support skin health.
5. Consult with skincare professionals before undergoing treatments like radio frequency or microneedling.

Introduction to Amitay Eshel: Discover how Amitay Eshel, co-founder of Young Goose, transitioned from a military career to pioneering in the biohacking skincare industry.Origins of Young Goose: Learn about the inception of Young Goose and how Amitay's experience with red light therapy and his wife's scientific background influenced their skincare line.The Science Behind Skincare: Amitay discusses the profound impact of scientifically formulated ingredients on skin health and how they differentiate Young Goose from other skincare brands.Debunking Skincare Myths: Amitay sheds light on common misconceptions about skincare ingredients and treatments, providing a clearer understanding of what truly benefits skin health.Innovative Skincare Ingredients: Explore the unique ingredients that make Young Goose products stand out, such as NAD and specialized peptides for skin rejuvenation and repair.Impact of Micro-Needling and Radio Frequency: Amitay explains the benefits of micro-needling and critically examines the efficacy and risks associated with radio frequency treatments in skincare.Advice on Skincare Purchases: Insights on how consumers can make informed skincare choices and the importance of understanding ingredient quality and product freshness.Young Goose's Approach to Product Freshness: Amitay emphasizes the company's commitment to providing the freshest ingredients by controlling the supply chain and minimizing product age.Future of Skincare Technology: Preview upcoming innovations from Young Goose, including advanced products that target the full spectrum of skin health and aging hallmarks.YougGoose use code BHB10 for 10% offOura RingLVLUP Health Use code biohackerblondie for 10% offhttps://www.instagram.com/young_goose_skincare/?hl=enhttps://www.instagram.com/biohackerblondie/https://www.biohackerblondie.com/Please note that the information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult a healthcare professional before making any changes to your health regimen.

People

Jenny Jones, Amitay Eshel

Companies

Young Goose

Guest Name(s):

Amitay Eshel

Content Warnings:

None

Jenny Jones
Welcome to another exciting episode of the Biohacker Bonding podcast, where we get into all things health, wellness, longevity, and, of course, biohacking. I'm your host, Jenny Jones, aka Biohacker Blondie. And today I am thrilled to welcome Amitai Eichelle, co founder of Young Goose, the innovative biohacking skincare brand that's redefined beauty standards through science. In this episode, we dive deep into the world of skincare, exploring groundbreaking techniques and debunking common myths surrounding popular treatments. Emmett Tighe brings his wealth of knowledge from his unique background in military strategy and red light therapy to the complex science of skincare.

Join us as we uncover the truths about ingredients, discuss the efficacy of treatments like microneedling and radio frequency, and learn about young Goose's commitment to creating products that not only promise to care for your skin, but actually deliver tangible results. Whether you're a skincare enthusiast or simply curious about how to better care for your skin, this conversation is packed with insightful, cutting edge information that will transform the way you think about skincare. So let's get started and unlock the secrets to healthier, more vibrant skin with Amitai Aisha. And if you wanna try their amazing skincare and transform your skincare routine with their clean, active ingredients, you can use my special discount code BHB ten at checkout to receive 10% off your purchase. Find the link in the show notes and experience the transformative effects of Yungoo skincare.

So now let's dive into this episode and uncover more about the fascinating world of biohacking skincare with Emma Ty. Okay, well, welcome to another amazing podcast, a Biohacker body podcast. And we are here with Amitai. Is that how you pronounce your name? Yeah.

Anastasia Eshel
Yeah. Okay, great. And he is the co founder of Young Goose, the number one biohacking skincare, which I honestly fell in love with. I bought your products at the biohacking conference last year, and a lot of products don't work well with my skin. I know, like, you know, there's so many brands out there that dermatologists love.

Amitay Eshel
A lot of them make me break out. I have very sensitive skin, and so it's been like a whole journey for me. I definitely have had acne pigmentation, but lasers done it all. So I want to hear about your magical biohacking skincare line, how this started, why you developed it, how you got into biohacking, and I have so many more questions, but let's get give a little intro, please, of how you got into this space. Sure.

Anastasia Eshel
So just to give just a small remark. I think what's different is that our skincare changes your skin. So it could be less reactive or whatever. But I'll tell you a little bit about myself. So as you said, my name is Amitai Eschel.

I am the co founder together with Anastasia, my wife of Jangos. But actually my first career was, was a military career. I was the head of recon for israeli special operations. And that's more dangerous than fighting wrinkles. And they pay you significantly less?

No, but the idea was, got out of the military and I really wanted to do something that combined what I've learned as far as like team building and combined something that contributed to people's lives. And I actually got hired. I was one of the heads of the world's, one of the first red light therapy companies. Oh, nice. I love red light.

Yeah. That's how I got into biohacking back then. Not only that, biohacking didn't exist really. Red light therapy didn't exist for that matter. And, you know, we've, we've to see what happens.

Obviously with it now is great. It's, you're, you feel vindicated. But also it was, there was a, an understanding because red light therapy is so vast, like the ability to, to affect mitochondria, you can really do it anywhere. So we can see anything from like, you know, you know, targeting the brain to targeting skin, anything in between. Right.

So we really, me as one of the people that built the messaging of that company, really needed to understand what people cared about. I mean, that was the first time that I understood people care about the way that they look. Because when you are in your twenties, a guy, a dude, you know, I didn't, you know, I didn't, didn't think twice about it. Yeah. Beauty and aging is, you know, a whole nother level these days, right?

Amitay Eshel
I mean, I was just listening. Someone was watching an old show and like, you know, the 25 year old had wrinkles and had these things going on. Now it's like everyone's like, I can't have any wrinkles. I can't. I want that baby skin, you know?

Anastasia Eshel
Yeah. Everyone's doing Botox at 18 to prevent, I don't know even what, but to prevent something.

Yeah, tell us. Yeah. So there's red light and everything, which I'm all passionate about. I have to ask you your favorite red light. And then you got a skincare.

Yeah. Well, that, when, when that company got sold, we really didn't know what we're going to do. We had that consultancy to try to help other companies do what we did with the red light therapy company. Anastasia, my wife, is a biologist, so she was doing liver fibrosis research, and I kind of pushed her to look into this molecule that's called nad. I was doing nad iv's cost over $1,000 in iv.

Back then, it was like $1,400 in IV. And I was like, wow, that's amazing. But I wish I could do it every day. But I realized that there is a cost of entry that most people wouldn't never be able to do, obviously, and also in the fashion that I liked it, which is intensely. So we try to develop a cream that goes transdermally, goes into your blood.

But we figured, we found out that the skin needs it to an extent that really, you cannot absorb more than an aging skin would need, because the skin is really being starved of it since your twenties, and it's a big culprit of why we age or why we sustain DNA damage. So the more we could give the skin, the more the skin could absorb, the more it needed, or not really the more it needed. But. But it wouldn't share with the rest of your body, wouldn't share with the bloodstream. It used it locally because it was so starved of Nad.

So we made lemonade, dia lemons. We made a skincare company, took, you know, it took five years of R and D. That. That short story. But that's the first products we had, was revolved.

They revolved around Nad. What we found is that it's not enough, even though we felt like we found this panacea, you know? And it makes sense, right? It's at the root of what aging is. Aging is really the accumulation of unrepaired damage.

And if you can give it the fuel for repair, which is, which is Nad, you should technically be able to solve all the problems. But we found out that the skin has no idea. A wrinkle is a problem or pigmentation is a problem, or laxity. Loose skin is a problem. Maybe eczema and dermatitis are things that the skin realizes are a problem because there is inflammation associated with them, and that we could actually, and that's not a medical claim, but we could actually resolve with those first NAD products.

But nothing that had to do with aging. And what we started doing is develop product around it that really gives the skin tasks, you know, repair wrinkles, repair pigmentation, repair laxity. And that's where we found the magic, the magic sauce in this. In this relationship. Wow.

Amitay Eshel
That is, I had no idea this was kind of telling your skin, hey, you need to fix, like, you need to get rid of these wrinkles or those pigmentation. So what are those specific ingredients? Or, you know, I'm sure I also know, like, there's so many factors that go into the skin, you know, what you're eating, what you're doing daily and your daily lifestyle. So, you know, we can always say, like, yes, we want that magic potion of that cream, but obviously there's like, drink water and stay hydrated and everything. So what else?

So what are those ingredients that guide nad to the skin and help, you know, prevent wrinkles, prevent pigmentation. So what we found is that you needed a combination of pro inflammatory agents. For example, vitamin A. Retinol is a great catalyst for repair. We also found that some of them are non ingredient based, like, um, peels and, and microneedling.

Anastasia Eshel
These are all things that, um, create controlled damage, controlled inflammation. And there's a. Yeah, I know, inflammation sounds bad, right? There is even something called inflammaging. Right?

So inflammation sounds horrible. But there is a difference between, um, acute, acute, local. Yeah, control show that it's, hey, you need to go, you know, fix this or. Well, exactly, exactly. If you think about it as instructions, okay, information.

It's the body's way to instruct repair. The problem is, if this is not resolved and accumulates in the end, you have a lot of background noise, like a lot of voices, you know, screaming or whispering, repair me. Repair me. So your body starts to fill up with that static noise or this background noise. And this is chronic inflammation.

And then even if we want to communicate, hey, please repair here, the body can't hear you because there's a lot, a lot of static, static noise, if you would. So we had to make sure that we are creating this signal in a responsible fashion. So vitamin C, that is not ascorbic acid. So ascorbic acid, we learned through the process, is on a, from a biohacking perspective, from a longevity perspective, is in a pro aging molecule, it actually ages you faster rather than size or something too. Like, if it's not encapsulated, kind of, there's oxygen it can do.

Encapsulation is mainly encapsulation. There is two things. Encapsulation can keep more of it stable until it reaches your skin. But the problem is high levels that we want in our skin of ascorbic acid, which is a synthetic version of vitamin C that is devoid from its full. It's not a full spectrum.

It's vitamin. You can think of it as vitamin C isolate, like equating to CBD fuel. So this type of vitamin C, very quickly, the tissue in very, in relatively low quantities, actually becomes pro inflammatory. It actually creates inflammation and which lead, which, you know, inflammation that is out of control and actually starts to, uh, excite, um, molecules like iron, by the way, that are, that are, that can be excited by, by oxidative stresses. It becomes, instead of antioxidants, become, becomes a pro oxidant.

It starts to increase oxidative stress in your skin, which damage which, which actually causes DNA damage. And also is, it basically causes theraposis. So it kills off cells, which, that is why it's used in cancer treatment to give an idea. So it's not like science doesn't know that. Yeah.

Amitay Eshel
Which one do you use then? What is looking out for? So just in general, not even if we use it or not, because we use two specific versions, but we mainly, just as a rule of thumb, we want to see some kind of mineral attached to the vitamin C. So for example, sodium ascorbate or calcium ascorbate are two that are very popular in supplements. So most, like high end supplements, are going to have one of those two versions.

Anastasia Eshel
What we use are versions that work very, very well with the skin and that you don't need high percentages of, which is THD ascorbate, which is fat based. So everything that we have that's fat based, we use THD ascorbate, and if we use water based formulas, we use magnesium ascorbyl phosphate, which is called map. Vitamin C. Ready to take your health to the next level? Discover the power of level up health's premium oral peptides.

Jenny Jones
I've been absolutely loving their comprehensive range, especially the gut repair formula, which features KPB and PPC 157, perfect for those looking to soothe and heal their digestive system. Don't forget to check out their liver detox and their tudka for optimal liver health and detox. And they even have ghkCU, a must have for radiant, youthful skin. Elevate your wellness routine with level up health and see the difference high quality peptides can make. As a special treat for my listeners, use the code biohacker blondie and that is biohacker Blondie Blondi at checkout.

For 10% off your purchase, just click the link in the show notes to start enhancing your health with level up health's exceptional peptides. Let's level up together. As far as phone, whereas ascorbic acid is not. So I put higher, higher levels, we disrupt skin barrier, things like that, which relies on a balanced ph level. Whereas all the molecules that I mentioned, even if you see in formulations, sodium ascorbate, it's normally very close to the natural ph of your skin.

Amitay Eshel
So you're saying to like to keep, to tell your body to go prevent these wrinkles, to prevent pigmentation. You're saying vitamin C is one of the main factors as also a supplement and or telling your body, yeah, so. So vitamin C is a cofactor for collagen, which is very important because. And we had to talk about collagen too because. Yeah, for sure.

Edward, people always ask, is this really doing anything for my skin? Because a lot of the times there's that whole conflict, right? Like, it's not doing anything, it's doing something. It's doing, it's doing something not actively, but passively. It supports.

Anastasia Eshel
So as a rule of thumb, your body, you know, almost as a whole, does not take in products and keeps them in their whole form. It normally breaks them down to a much more easily shuttled molecules, amino acids, whatever that may be. And then it reassembles that at the, at the end, at the end terminal, if you would. And collagen is no different. Collagen is broken down to its amino acids and then it's utilized to create connective tissue or to create, you know, those amino acids are used also in muscle synthesis.

It's, they're also used in, in different, many different types of cells. But if you have abundance of glycine, for example, your skin is going to have an easier time creating collagen, for example. So it's not that it doesn't support it, but you're more like replenishing reservoirs that you might be deficient on. You might not be. So that's more of the discussion.

But you do need, by the way, you do need vitamin C. So vitamin C is crucial because especially the supplement. Go to my supplement go to. I have two. Is it liposomal?

I know that, you know, yeah, it doesn't really matter. I have to say it doesn't really matter in vitamin C. It's, it's uh, I don't want to take anyone's livelihood away, but it doesn't really matter. Uh, but I do one form that is liposomal that I take because I lie. I again, vitamin C, I want it to be pure, I want it to be stable.

I want it to be treated well. So uh, quicksilver scientific, um, like Chris. Yeah, uh, Chris shade they on and. They'Re and they're charcoal. They're viner, which I love.

So it's, it's a, they have a really good vitamin C. It's sodium ascorbate, by the way, and another. So I prefer sodium ascorbate as a supplement. Um, and another one that you need to normally get through physicians. It's called pure c.

It's pur c. Okay. Oh, yeah, I haven't tried that one. I really like, I just like the flavor. And I know, you know, symbiotica, too, has some great little, like, liposomal flavored packets.

Amitay Eshel
But the peak, the peak life, the vitamin C, I love that. So my only issue is refrigeration. So, again, I don't know symbiotic, but I don't know the owners. I've met their spokesperson a few times. Yeah.

Anastasia Eshel
As far as I know, most of the products. And again, by the way, that's. I haven't gone and look, but most of the time, when you buy it for a practitioner, when you buy it from whoever, it's not refrigerated. Therefore, it seems to me like it's not part of the company lore. It's not part of the.

Is kind of not something that the company kind of puts their mind to do to refrigerate their products. Therefore, you refrigerated? I. Preferably, yeah. Oh, preferably.

Again, if it's in a closed bottle, that's fine, but preferably, it should be refrigerated because it does. It does degrade. It does, you know. Yeah, I know. There's also expiration.

Right? Like, even with skincare products. I'm curious, like, how long, you know, do these skincare products last? I don't think you're opening. You're opening a pandora's box.

Amitay Eshel
I want to know. I mean, is it still good? And your stuff lasts for a while, too. It's, you know, like, it's a little bit more, I guess, on the expensive side, I guess, on your typical, you know, counter brands. But it lasts a long time, so.

Anastasia Eshel
So I will refrigerate them as well if I. If I. They don't need to be. We have a, that's called a double wall, so we have vacuum, literally. It's the most insulated packaging you can find.

A lot of people would have some complaints around the packaging. Oh, you know, the letters ran out or something like that. The materials we use for the packaging are heavily insulated, so, technically speaking, you don't need to. I would do it anyway because, you know, you know, why not keep it fresh. I would tell you something about, about skincare in general.

Skincare needs to be sold within two years from when it's made normally, most companies don't really adhere to that. So most of the products that you buy are around two years old. Not. Yeah, not only that. Not only that.

Now, now we're getting into the weeds.

I can go to a distributor of ingredients, and there are not a lot of them. There are. There are a few of them that sell most ingredients in bulk. I can tell them, hey, I would like to buy this product at that grade from a suitable grade, you know, whatever. There is no medical grade.

That's. That's a made up term, but different grades. I can buy it just before I can buy a five year old ingredient. So when you buy a product and it's like, you know, and hyaluronic acid is not what you should be looking for anyway, but let's say you were looking for hyaluronic acid, and you buy a product that's, you know, six, 8% hyaluronic acid, and it costs, you know, $10, you're probably getting a seven year old hyaluronic acid. Yeah.

Amitay Eshel
That is horrible. The difference that, by the way, what I'm saying right now, I'm paraphrasing someone else, but. But it's true. The discrepancy in skincare ingredients between companies, between qualities is larger, between the discrepancy, between McDonald's meat and the meat at whole foods. Oh, my God.

So how do you know? I mean, what can you do? Is there any research, I guess, or you can look at the expiration date or when it was made and you know, or you just have to know the companies and know there. So a lot of the times, a lot of the times, it helps to know who behind, who is behind the company. It helps to know what the mission of the company is.

Anastasia Eshel
Most companies are not going to talk about the life of the product, so we normally communicate that, which is very difficult. So we aim at supplying you with a product that we bought. The ingredients at their freshest, a lot of the ingredients we process ourselves. I actually did not finish answering the question about our products promote skin rejuvenation, but a lot of the algae and things like that, not only that we process ourselves, we serve other companies in processing it for them as well, but so they're fresh. And the other thing is that we aim at selling you a product that is around two, three months old.

The problem is, a lot of the time, you know, we're not a lot of time. But for example, as we speak, our cleanser that one of the, the algae extracts there due to climate conditions, et cetera, we're just behind. Like there are people who are waiting two weeks for their cleanser right now. It doesn't happen often, but it does happen sometimes, and people tend to get upset about that. The alternative is selling them is creating a lot of product and saying, well, you know, maybe it's going to take us one year, two years to get through that product.

This is a cheaper way to go, by the way. So someone would say, well, if you were a larger company and you didn't sell, you know, 10,000 orders a month, you sold, you know, a million orders a month or whatever, then you would do that. To which I say, actually, it's, it's cheaper. If I, if we invested more money in making a lot of products at once, we would have saved a lot of costs. Yeah, you would have gotten a much older product at the end of the day, but it is much cheaper to create larger amounts.

Amitay Eshel
I mean, people do not think about this when they're buying a product, what goes behind the scenes, you know, and how the quality of a product, even skincare, I'm not thinking like, I'm always, of course, thinking about this with food, somewhat supplements, you know, but I didn't even think about how kind of this can be corrupt with skincare as well. Is it even active? Is it even most companies? Most companies. So right now the world's very interested in clean skincare, which is fine, you know, to each his own.

Anastasia Eshel
I think most companies are clean washing, which means that they have, their formulas are extremely basic. They actually don't have anti, don't have active ingredients there. Yeah. Therefore, and they don't even test for the fact that for bacterial growth. Oh, and I just do that.

Yeah, yeah, yeah. With algae. I love algae. I think, you know, I did a, you know, a podcast all about like, the oral microbiome. And algae is so important for just like, you know, keeping that, like, homeostasis of bacteria in your oral microbiome.

Amitay Eshel
So I'm sure, like the skin, you need that to like, you know, that bacteria. The challenge with algae and the reason that we are specialists in algae is not because we have a technology that other people don't have, per se. It's because algae has a lot of heavy metals, normally pollutants, heavy metals, and no one else tests for that, that I know of no other skincare company tests for. Yeah, we have a third party testing. And another thing about it is that your skin, there is a phenomenon that's called, so we've pioneered leaky skin a few years ago and now I start seeing in different places there is another, another phenomenon that's called sticky skin.

Anastasia Eshel
Sticky skin, it means pollutants like carbon monoxide, glyphosates and heavy metals actually adhere to the skin. And they, they can't really, the skin can't really shed them. It doesn't have the mechanisms, the enzymes, et cetera, to shed them, to release them. So, so they build on top of the skin and age the skin. Of course.

Amitay Eshel
What can we do for sticky skin? Cause I like, I would love to do more exfoliation. Well, that, you know what would really help? Red algae extract can actually build. There are two things, but bread algae extract and a product called ectoin, which is a protein.

Anastasia Eshel
It's really cool protein. They can build a layer around cells and kind of not let they resolve leaky stick, leaky skin, if you will. So our cleanser would have that, but you could find other brands who have it as well. Yeah, so I never heard of sticky skin. Oh my gosh.

Amitay Eshel
So yeah, so what is your whole, and you also have peptides in your skincare. I'm all about peptides right now. So what are your go to peptides? I'm loving ght U. Is that in your skincare or a habit in your skincare?

Anastasia Eshel
Yes, but I hate to bum you out. Why are you getting rid of it? No, because peptides are not great as leading ingredients in skincare. They can be utilized. But the, if you really want results from peptides, preferably inject them or take them orally.

Amitay Eshel
Yeah. In skincare they do not have what we call high affinity. So if I put, you know, ten milligrams of GhkCU topically on your skin, not the entire ten milligrams will absorb well, will stay in the skin, will function well and will be equal to ten milligrams that reached the same place due to injection. What about microneedling? Microneedling is great.

Like a peptide with GhkcU or something. Have you been. That's okay. But we're still, we still have, one of the problems with GHKCU is that it builds, it helps your skin build collagen scaffolding. So it doesn't create any signal for repair or anything like that.

Anastasia Eshel
But it supports the repair process. But if I still move my face in a predictable fashion, this layer doesn't really do much for the repair process. Another example, if we inject stem cells into my shoulder because they have a torn rotator cuff. They're telling you don't go ahead now and lift weights like beforehand. Try to do overhand over over shoulder press says like before the injury.

Wait a while. Let those scaffoldings be strong enough to support that. So when we use GhkCU, we pair it. And that's the only way to have GhK, GhkCU or what it, what is called in the, according to the FDA, like if you want to see the back of the, of a label, if you want to see if GhKC is there called copper tripeptide one.

If you want it to work, you have to have neural peptides next to it within the same complex. You have to. A few of them are argurelin. Arguellin is probably the most famous one kind of sister molecule to arguelin that works better around the eyes but less well around the entire face. It's called snap eight.

And a newer one, a new player that we use, tailor made compounding uses, I'm sure other people use it too, is called lupacil. So we use our durelin, Lupacil and ghkcu. And those are better absorbed with that. They're not there. They're improving.

Not only the, they don't improve absorption per se, but they improve the, they support the function so they support the, they prevent the skin in contracting in predictable fashion. So they exhaust the synapse that the nerve. So if your nerve is firing, it's not going to have enough material to fire again in the same place. So you're. Another nerve is going to fire.

So you're, you're not accumulating movement in the same place which allows with time more of those uh, processes, the renewal processes to take hold. Yeah. Quick question and I've heard of this salmon semen they're injecting like in the skin and that they're saying it's because of the stem cells. Have you heard of this? So it's funny what people, it's funny what people like gravitate towards, right?

Because if you really wanted to inject something it would be porcine growth factors and stem cells from, from pork. They're more. Yeah, they're from, from, from pigs. These are more biocompatible to us. Uh huh.

Yeah. But, and we actually. The reason we're. Or real stem cells from pigs, they're dead though. They're dead.

When you say the fish ones, the ones from pigs, they're all dead. Only the stem cells and the growth factor, like, excuse me, only the growth factors and just the growth factors. And some mate. Some growth factors that are wrapped around some matrixes. Matrices are active.

Some inflammatory cytokines might be active too, but like, they're dead. Pig stems. The pig stem cells. Pig stem cells. And.

Yeah. And then you can actually, you can actually see raises in NAD, by the way. What? Yes. And we already have, we already have like what we call like stage two NaD boosting complex, which we don't have out yet.

We're probably going to have it in like a year or two, which is vegan. Vegan. But is mimicking the effects of, of those porous, porcine stem cells. Yeah. Wow.

Amitay Eshel
Oh, my gosh. That's so interesting. Okay, so what have you done? I just am so curious. What are your favorite, you know, facials?

I know there's like exosome facials, lasers, stem cells, there's all of that. So what is your go to? And also I have been struggling with pigmentation. I think pigmentation is the hardest thing. And I'm really trying to detox my liver.

And I know those two go hand in hand. So I want to know all your steps on how to look beautiful and have gorgeous skin. Okay, so first of all, you asked me about facials, and I think, I think facials are, you mentioned micro needling. I think micro needling is like number one that you should be getting from professional. You could do it at home, but it's actually not the same thing.

Anastasia Eshel
It's literally not the same thing. There is, it's not like I'm getting less or whatever by this space because. I know there's the doctor pen. I'm scared to use it because I know there's different levels, like different lengths of the needle going in, and you need to use different lengths of needles in different areas. Right.

Amitay Eshel
Like if your cheeks are fattier versus, like maybe around your eyes. So it doesn't really matter. It doesn't really matter. What matters is what you can take. But, but in general, for home use, we have 0.5, sorry, 0.25 and 0.5.

Okay. Professionals normally would go around 1 mm. Okay. Why is that important? Because 0.25 or 0.5 doesn't do much for collagen or for elastin or to really create a denser matrix.

Okay. It mainly thickens the upper layers of the skin, which is great, which you need, which is important for longevity, which is important for resilience. Looking to optimize your sleep and stay on top of your health. Check out the Oura ring, the ultimate tool for health enthusiasts who want to take control of their well being. This sleek, smart ring effortlessly tracks your sleep patterns, helping you understand your body better, better and make informed decisions about your rest, recovery, and overall health.

Jenny Jones
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Don't just sleep better, live better with aura. Do it. Do it. I actually like derma stamping. Okay.

Anastasia Eshel
The problem with rollers, not Doctor Penn. Doctor Penn is mimicking a professional device. Now, by the way, I think, I don't know if they have it in the United States, but Dermapen, which is my favorite company, I have no financial interest in that on purpose, by the way. But Dermapen, we spoke about kind of knowing who's behind the scenes. I just saw behind the scenes in America especially.

I know the family behind Dermapen, australian family, and I know the people who represent them here in the states, and I know they're good people. So that's very important. And I know they have a home device, okay? I don't know if they have it in the United States. I know they have it in Europe, but I'm assuming they have it in the United States.

If not, it's a mistake. Derma pen. Go ahead, do it. But I'm. What I like the least is the derma rollers, okay?

And the reason is because derma rollers, when you roll, first of all, it's not disposable. And the number one rule in microneedling is sterility, okay? Is not reusing something we've used on the skin. Even if you don't, you're not getting infectious infection per se. You are getting some material that is irritating, which will not give you as good of a result.

Irritation. Irritation. And in general, your immune system. Active. Active is not something you want if you want to create renewal, okay?

Amitay Eshel
Yeah. Because you're. You're going to create scarring. But another thing about derma rollers is that the needles don't enter the skin in 90 degrees because you're rolling it on your skin, okay? They bore a little bit in the skin, and they do not exit in 90 degrees.

Wow. I think of this, you're creating a more collateral damage. Oh, okay. Yeah. So.

Anastasia Eshel
So I recommend Derma stamping. It's. It's really inexpensive. I like it because you can. It's.

The heads are disposable. You can get new heads all the time. Very easy. Yeah. When we talk about professional micro needling, what I want to see, um, what I'm.

I'm going to look for as a, um. As a client is, uh, a robust onboarding process. Okay. For example. Why am I saying that?

Because you shouldn't be doing micro needling if you have an ongoing conditioning conditions such as eczema, acne, things like that. Rosacea is problematic. And in general, um, in general, because normally there is aftercare involved and other things done. I want to see a professional that is. That.

That is tailoring a bespoke treatment to that specific. To that specific client. So if you're not going through. And I want to see the sterility of the place, etcetera, very important. If you're not getting through that process, if you don't get kind of interrogated a little bit before you get your first.

At least your first, you know, treatment done, it doesn't tell me good things about the place that you're going to. I would say, as a caveat, micro needling radio frequency is a crime.

It should be investigated and people should be sent to jail.

You are. What is the facial called? The morpheus. Morpheus aid. Is that problem.

It's a problem because they're israeli and I'm israeli, so it's hard for me to say. But radio frequency in general is a sham. It's a hoax. Why do you say that?

Have you ever. Have you ever done microneedling? Hey, sorry. Have you ever done radio frequency? I've done the morpheus a.

Amitay Eshel
Morpheus a. Great. So you'll be. You'll be my. I'm going to get you on the stand for testimony.

Anastasia Eshel
When did they tell you to come back? How often?

Amitay Eshel
I think it was like every six weeks or something. Okay, so for the first three to six months, your skin is recovering. What we're doing is we're. We're not actually treating the skin. Okay.

Anastasia Eshel
These micro needles, by the way, radio frequency with micro needles or without. We're just going to kind of use a blanket term here. But those needles, or the energy itself delivers energy. Remember we spoke about millimeters. Yeah.

About 3.5 mm into the skin. So before that, we were talking about 1 mm. Now we're talking 3.5 beyond the skin surface beyond the skin to a deeper tissue. Yeah, but it hurt. You are the result that you think you see.

The results that you think you see are not de rejuvenation results. What they claim as it makes you create more collagen. Right. Whatever that the claim may be firming or whatever. What you're seeing is inflammation.

What you're seeing is swelling of the tissue, all right? The same way if you punched me around my eye, I'm gonna get swelling. Yeah. So you get. You get swelling of the tissue.

Amitay Eshel
Be gone. No.

Anastasia Eshel
And this swelling takes around three to six months to resolve itself. Wow. And by the way, what I'm telling you right now, the person who recommended it to you, the person who did it to you, the person who sold them the device, even all of those people, maybe the person who sold the device, a little bit different. But all of the people that you were interacting with, I would assume they don't know what I'm saying right now. Okay.

But if you talk to a plastic surgeon, he will. He will. He will corroborate what I'm saying. So that energy. So you have three to six month that you don't see the results of radio frequency, you don't see the rejuvenation results.

And after three to six months, normally after six weeks, you start seeing the resolution of the swelling. And that's why they bring you in, because the results went away. I'm doing air quotes to anyone who's listening. The results went away. Okay, but what went away?

We created collagen or we didn't. What exactly went away? The swelling went away. What you're left with is a fine scar tissue below your skin that moves in a very rigid fashion. And according to 2022, one of the new hallmarks of aging is mechanical alterations.

So from a biological point of view, you've aged your skin. That's number one. Number two, you have to destroy vascularity, okay? So you have less blood vessels getting there, which in and on its own is a form of aging. Yeah.

But if you wanted to microneedling afterwards, guess what you're doing? You're creating information so blood supply could come to the area together with, you know, whatever you need. That is your supply trucks, right? Yeah. So you're decreasing the highways of supply.

And, you know, if you ever wanted to do plastic surgery or laser resurfacing or whatever you wanted to do, that is more robust, your skin has less tools to deal with that, which actually would then create impaired healing. So when a plastic surgeon addresses a tissue, he will ask you if you've ever done radio frequency, because the. His ability to create good results are now impaired. Yeah. And by the way, that's something just.

No one needs. No one needs to believe me. No one is. One needs to listen to this because, yeah, I'm. I'm very concerned, and I know people.

Amitay Eshel
I feel like they intuitively know that these lasers are causing long term damage. I think lasers. Lasers are a little different. Lasers are overinflated in their. In the promise of results.

Anastasia Eshel
Yeah, I think fraxel, any type of, like, laser resurfacing, doing it every, like, five years. Halo, BB, laser, whatever. Clear and brilliant. Same company, just Cyton, whatever we said right now, it's all Cytok products. They are good.

They're great, but they are robust. Okay, why am I saying once every five years? Because what you are doing is you are calling on a lot of reservoirs that your skin is keeping for the future. So if you have a traumatic event, emotionally or physically, if you're gonna have, you know, lack of sleep, let's say you have a newborn, like I do, or a grandbaby that you need to help, or, God forbid, you encounter grief, anxiety, anything like that. Your body is now in a state where it requires those reservoirs.

And your skin does as well because it needs to deal with a lot of catecholamines, which are like stress molecules, mainly in the brain, but they also propagate in the body, like, for example, like cortisol. So, elevated levels of cortisol, it causes something called mmp. MMp two, which breaks down collagen. So now we need, for example, all of those reservoirs that we've withdrawn from our bank. Yeah.

And now we cannot. We don't have as much of them. But in general, if we are interested in playing that game between looking our best but also being. I don't like the word biologically younger, but I'll just say it here. And being biologically younger, they do not normally correlate with one another.

If I do what Brian Johnson does, for example, and every month, logical age. You know, and I love Brian, and I love what he's doing, and there's all the crazy stuff he's doing. But I'm just. Sometimes these biological age, I'm like, well, you don't really look your biological age. Well, first of all.

First of all, there is no such thing. Yeah. It doesn't exist. Biological age. That you might need to take it three times to kind of even get, like, an average is even.

No, no, it doesn't exist. It doesn't exist. There's no. There's no. There's no, um.

Amitay Eshel
You can't combine all the different parts of your cells and all the different of aging into one text. That's what I, um. They don't compute. You're. You're looking at factors that do not.

Anastasia Eshel
Do not have any sub factors are the same. We say in Hebrew, the same lady with a different dress. Okay. But some factors really do not commute. They actually have nothing to do with one another.

You know, I think. I think telomere length is probably the most overhyped process as far as aging, because it really has nothing to do with aging. It is an expression of your body's current state, but it has nothing to do with aging as a whole in our body. So. But we can talk about.

We can talk about a lot of it. We can talk about something like, again, like a mechanical. Mechanical alterations. So let's say someone broke their hip beforehand. They will be a certain biological age immediately after they broke their hip.

I would argue you are 20 years older biologically. So it's not linear. It's hard to think of. I like to think of functional age. Okay.

Rather than biological age. Functional age. I can say, you know, right now, my cells are behaving at a certain level. Yeah. Yeah.

I could take them back forward. Biological age. I know you can take the test maybe six months later, and now you decrease your biological age by ten years. So. Yeah.

Amitay Eshel
But I guess it's a good hallmark, maybe, of just encouraging people to, as well, healthier. Yeah. Like choices. It's a good game. Yeah.

Anastasia Eshel
Yeah. And it's fun. And whatever is fun and leads you to down a positive path, go for it. But thinking about the skin, someone. Someone as inspirational, as important for our community as Brian Johnson.

He's important because he cares. Yeah. That's. That's mainly why does things that are. That are with unequivocally making him biologically older in his skin.

Biologically older only to appear younger. He's problematic because without a doubt, these cells are. Now, you could divide your skin's performance to three things. So many lasers all the time. I'm curious about this, too, because I'm like, he's doing them a lot.

Yeah. And I've seen many times in person and gone on hikes and everything, and I've seen his skin, but I'm like, I'm curious. Yeah. If he's. And I know he just did the fullest stat and the gene therapy.

Amitay Eshel
And I think that's really helping a lot with skin and muscle tone and everything. And so that's helped his skin. But I'm curious your thoughts. When you're doing lasers, like every week or every two weeks on your face, it seems like it's too much inflammation. Right?

Anastasia Eshel
That's. Yeah. And, and again, like, you can look at the skin in three different. Three different approaches. One is what we call optimal performance.

It's your. Your perceived age. How old do you look? Okay. Yeah.

Look, think. Imagine a Venn diagram. Okay? One. One bubble is optimal performance.

Another is resilience. Okay. It means if I have a traumatic event, if I have a month, that I didn't sleep well, or whatever that is. Yeah. Why am I saying didn't sleep well?

Just to. Just to go down very short tangent, if I don't sleep well, I have significantly higher sensitive, higher. A decreased ability to clear glucose from my blood. That in turn, propagates something called age advanced glycation. End product.

These advanced. And. Which is, which is now a hallmark of aging. Glycation is a hallmark of aging, yeah. These attach to proteins such as collagen, and basically renders them dysfunctional.

So you get thinner skin, you get more crepey skin, you get less elastics in etcetera. So I took you down that path. Of, like, bags under the eyes is a sign of you're not getting sleep. It's crazy how you're. And it's a.

And it's a sign of glycation, too. Yeah. And you'll see that on the skin. It's like your effect of not sleeping, or maybe with sugar, is like. You see that right in the skin.

Yeah. So, so. And we're always in a battle with glycation. Okay. Glycation is something, again, we talked about biological age.

It seems like it's something finite, even though it's a hallmark of aging, we can do things to reverse that. GHk sea is actually pretty good around the eyes. And also estradiol cream for people who are post menopausal. Uh, 2% Israel creams around cream around the eyes. Pretty good for that.

Um, but. So, resilience is super, super, super important because that is what, what. Especially women that are going through menopause, uh, pre menopause and menopausal women are going to have a few points in their lives, late twenties, late thirties, kind of late forties or early fifties, where they're going to feel they aged overnight. And that has to do with resilience to hormonal changes. But the fact that the skin ages so rapidly it's deteriorated resilience, and the third is real longevity.

Okay, how many of the reservoirs am I kind of using now? How many am I losing later? Where can we see it? We can see. Again, I said the term doesn't exist, but it is being used.

It's called medical grade skincare. So things like obagi, Zoe, skinceuticals, you know, can think of many other brands since they were. Yeah. So they're a little bit older. And what they propagated for profess for many years is the, the need for exfoliation.

And you, since you, you mentioned that, I'm assuming you are familiar with the messaging of these brands. Yeah. And the problem is, is that if you, if you follow that Venn diagram, you're realizing that you're harming a lot of the longevity of your skin. And now we know how it looks like because we can see people who have been using these modalities for 2030 years, and we can see thin, thin, paper thin skin. We can see skin that has exhausted its.

I hate to go back to something I bashed, which is telomere lake, but we can see skin that has exhausted its ability to replicate. Is this also with retinol, like tretinoin? I know that they say, like, it can make your skin too thin. Too thin. Yeah.

You know what we're getting back to now? We're getting back to vitamin C. So vitamin C, the lack of vitamin C will lead to the fact that the stimulation for collagen production you're getting from retinoids is not being met adequately, and you're going to have thinner skin, whereas what you really want from retinoids, this thicker skin, what I would, what I would want to kind of introduce to you is the concept that retinol, or vitamin A's in general, are only active in your skin, are only in their active form in your skin for 24 hours. Then they get esterified, they're being stored. So again, the older model of treating vitamin A's, which is retinal, retinal, tretinoin, retinoic acid, etcetera, like there are some kind of, like, appeal, some kind of glycolic appeal, some kind of broad irritant that, that breeds positive results, is again outdated.

We really need to adjust our approach to retinals that we can, with that, we can apply on our skin most evenings, if not every night. Yeah, I know. The, the trend, the one that I've used, it's. I mean, I can only use it once, twice a week. I mean, I'm feeling, yeah.

Amitay Eshel
And yours, though, I don't know what is in yours, but it feels like honey over the, like, it's like this smooth, silky honey. Yeah. Over the face. What, what exactly is in it? What makes it doesn't irritate my skin?

Anastasia Eshel
It's encapsulated in biomimetic lipids. So when your skin. So the negative effects that that has nothing to do with skin renewal of retinol is damaging your skin barrier. So we are feeding your skin barrier while infusing retinol into your skin. And the real, the real goal is to allow you to use retinol every night, obviously building up to it, or at least most diets.

And I know people who use it even twice a day. But again, to kind of answer your first question, these are some of the more standard molecules that we used to invigorate the skin or to create renewal. The best molecule we found is actually spermidine. Oh, interesting. So, spermidine, do you also supplement with it as well?

Yes, yes. I take twice the highest amount of spermidine you can take as far as, like, oh, I love it. Okay. Yeah. But spermidine, you know, it's a molecule that we still learn.

We're still in the process of learning how important it is. But what it does do, it encodes, genetically encodes autophagy. We used to think that it mimics fasting, that it tricks the body to, to increase autophagy, which is cellular recycling, if you would. But what we do, zombie cells are senescent cells. Zombie cells are impacted by it, but it actually recycles damaged parts as well.

And what we understand now is it's more like a chimney. It does take out damaged parts. Right. But it pulls after it more renewal, like a chimney, is going to pull air also kind of into the furnace and going to stoke the flames. It stokes the flames of repair.

And the results we're getting by our two products, youth reset and youth daily, which we went back to. We were, yeah, yeah, yeah. They're brand new. Like, wait, I didn't know about this product. And now installed on your website, so I'm gonna have to order that.

We actually are selling out very quickly from it. And. But we're, we went back to the lab. You know, by the time the podcast air, we might be in a few weeks of it being on backorder. But the new version of it, we realized how revolutionary that is, and we created a bunch of, like, different molecules around it that support its function.

Were creating something sick, really, in the that's really, I believe, is skincare 2.0. Wow. Yeah. Because it targets every. So there are now twelve hallmarks of aging.

I would argue there are 24, but it targets the entire twelve hallmark of aging gamut. It's going to be a skincare like a line of we want. We're gonna, we're gonna introduce that concept to more and more of our skincare line. But for now, it's going to be a serum that's called youth reset and a cream that's called youth daily. But in the future, more and more products are going to kind of take on themselves that approach as well.

The real standout is the hyperbaric mask, where we actually are going a different direction with it. And it's such a unique product that we are actually going to target different mechanisms that you cannot target with other products because of its delivery system. We can do some crazy things with it as well. Do you guys just have a lab that's doing all this research? Twenty four seven.

Two of them. But you're spot on in your question about the 24 hours. We reinvest 90% of our profits back into R and D. Wow. That's why I don't have more books behind me, because I don't have, you know, there's no money to buy the books.

No, but that's, that's one thing I. You know, I don't think a lot of people know about yungus. Like, I mean, in our biohacking longevity space, everyone knows, of course, but a lot of people just know, you know, Abagi and all those brands. And I have tried all of them, and I feel like I've never really seen great results. They've agitated my skin.

Amitay Eshel
And I've also tried very clean products that are known as well. But I don't feel like, like I think you're right. Like, they are clean, but they're not being. Doing much. It's just cleansing the skin, you know?

And so this is such a great skincare because it's being active, it's great ingredients, it's doing something, and it's clean, you know? And then obviously, now we're talking about how it's backed up by, you know, uh, not expired ingredients. Yeah. So that's, that's what we call pro youth skincare. There is no such thing as anti aging.

Anastasia Eshel
Right. That doesn't actually meant, mean anything anti aging. I actually want to do a shirt anti anti aging club. Um, but, but what our skincare is, it's pro youth. It propagates you.

And we got a. I have a hard stop. But I do want to say that the idea is so, so we invest a lot in R and D, and our idea is to not be. We don't want only our success. I think as evidence to that, we actually have skin care line for younger people that we believe in.

That's called Siv. Sieve that we offer on our website because we believe younger people with. With this. With biome disbalance in the skin, they need that product.

We have, you know, there are maybe ten other companies that have ineffective, but still nad in their skincare right now. We don't. We don't want to be in a vacuum, but we do want to lead the industry to a better place and that everyone will get the results that they're paying for. Because this is a multi trillion dollar industry that is built mainly on false promises or empty promises. I know.

Amitay Eshel
I know. It's a huge. You know, especially women. We all want to look beautiful and young, and people will pay money. And I have paid a lot of money trying things that just sit on my counter because they didn't do much, you know, but I paid so much, like, for these products.

Anastasia Eshel
The joke is that they're as effective sitting on your counter as sitting on your skin. But. Yeah, but what we're. Again, but that's. That's our goal.

Right? And, yeah, I'm so sorry. We. The great conversation. Thank you.

Amitay Eshel
So I've learned so much. So thank you. And I'm sure the listeners are going to love this. I cannot wait to bring this out on the Biohacker Blondie podcast. This is so great.

So everyone go check out young goose. It's younggoose.com amazing products. And you're coming out with even more amazing products. So everyone go check them out, because really, this skincare is everything. It doesn't agitate the skin.

It's clean. It's great ingredients. So, anyways, but thank you so much for coming on. I will let you go, and I hope you have a wonderful day. Thank you so much.

Okay. Have a great day. That's all for today's episode. If you enjoyed our deep dive into the world of advanced skincare with Emitai Eshel from young Goose, don't keep it to yourself. Share it and leave a review.

Jenny Jones
I'd love to hear your thoughts and experiences. Make sure to pass this episode along to your favorite person who's just as passionate about skincare and wellness as you are. Stay tuned for more inspiration insightful episodes here on the Biohacker Blondie podcast where we continue to explore the exciting intersections of health, science and technology. Thanks for listening and remember to keep hacking your way to better health.