Listen to the latest episode with Chris Mirabile, founder of Novos Labs, as he reveals Novos Labs key supplement stack for longevity and shares insights on various strategies to extend your lifespan.

This episode explores Novos Labs' innovative approaches to health and longevity, focusing on their key supplement stack designed to address the hallmarks of aging.

1. Novos Labs' supplement stack is designed to reduce the biological hallmarks of aging.
2. Lifestyle choices have a significant impact on aging, with genetics playing a smaller role.
3. The Novos Life mobile app offers tools for tracking and improving one's biological age.
4. Chris Mirabile's personal health challenges led him to focus on longevity and creating Novos Labs.
5. Practical advice on diet, sleep, and supplementation to enhance overall well-being.

1. Introduction to Chris and Novos Labs

Jenny Jones introduces Chris Mirabile and discusses the founding of Novos Labs. Chris shares his personal health journey. Chris Mirabile: "I started Novos Labs to help others achieve better health and longevity based on my own experiences."

2. Understanding Aging and Supplements

In-depth discussion on how Novos Labs' supplements address aging. Chris explains the science behind each ingredient. Chris Mirabile: "Our products are formulated to target the biological mechanisms that influence aging."

3. Practical Longevity Tips

Chris provides actionable advice on improving sleep, diet, and utilizing the Novos Life app for health optimization. Chris Mirabile: "Simple changes in your daily routine can significantly enhance your health and longevity."

4. Q&A with Listeners

Jenny and Chris answer listener questions about longevity strategies and the efficacy of supplements. Chris Mirabile: "It's about making informed choices that contribute to long-term health."

1. Regularly monitor your biological age using tools like the Novos Life app.
2. Incorporate a Mediterranean diet to support longevity.
3. Prioritize sleep as a fundamental aspect of health.
4. Consider supplements that target aging at the cellular level.
5. Engage in regular physical activity tailored to your health status.

Takeaways

Understanding the 12 hallmarks of aging and their impact on health and longevity.Insight into the development and science behind Novo's Core formulation.Controversy surrounding the effectiveness of spermidine and the role of antioxidants in exercise.The role of multivitamins in addressing nutrient inadequacies and the importance of blood work for personalized health optimization. Supplements like multivitamins, fish oil, and vitamin D are discussed as part of a daily health regimen.The controversy around fish oil and the importance of high-quality, low-oxidation fish oil are highlighted.The concept of biological age and the significance of epigenetic tests in measuring it are explained in detail.The impact of sleep on overall health and the importance of a good sleep routine are emphasized.The Novos Longevity Diet, a Mediterranean-style diet with a focus on whole foods, is discussed as a beneficial dietary approach. Practical lifestyle choices play a significant role in optimizing health and longevity.The Novos product line, especially Novos Core, is backed by scientific research and evidence.The launch of the Novos Life mobile app provides a free biological age test, lifestyle score, and daily recommendations for improving health.Facial AI technology, such as the Face Age feature, offers insights into facial health markers and actionable steps for improvement.Simple biohacks, such as improving sleep quality and using light therapy, can have a positive impact on overall health and well-being.Novos Labshttps://apps.apple.com/us/app/novos-life/id6468173076https://www.instagram.com/novoslabs/?hl=enOura RingBiohack For Life Bookhttps://www.biohackerblondie.com/https://www.instagram.com/biohackerblondie/?hl=enDisclaimer: The information shared in this episode is for educational and informational purposes only and is not intended as medical advice. Always consult with a healthcare professional before starting any new supplement or health regimen.

People

Chris Mirabile, Jenny Jones

Companies

Novos Labs

Books

None

Guest Name(s):

Chris Mirabile

Content Warnings:

None

Jenny Jones
Welcome to another episode of the Biohacker Blondie podcast, where we get into all things health, wellness, longevity, and of course, biohacking. I'm your host, Jenny Jones, aka Biohacker Blondie. We have an exciting episode with a truly inspiring guest, Chris Mirabel, the founder of Novos Labs. Chris joins us to share his personal health journey and the creation of Novos Labs, a company dedicated to longevity and health optimization. So we dive into a wide range of topics, starting with an in depth look at the twelve hallmarks of aging and how they impact our health and longevity.

Chris explains the science behind the development of Novos core supplement stack. Their flagship product reduces the hallmarks of aging and the controversy surrounding ingredients like spermidine and fish oil. We also explore the crucial role of multivitamins in addressing nutrient inadequacies and the importance of blood work for personalized health. Chris shares his insights on the concept of biological age and the significance of epigenetic tests in measuring it, along with practical tips on improving sleep and the benefits of the Novos longevity diet, a mediterranean lifestyle diet. Additionally, we discuss the exciting launch of the Novos Life mobile app, which offers a free biological age test, lifestyle score, and daily health recommendations.

Chris introduces us to the innovative face age, utilizing facial AI technology to provide insights into facial health markers and actionable steps for improvement. Throughout our conversation, Chris emphasizes the importance of practical lifestyle choices and the simple biology, such as light therapy, to enhance overall health and wellbeing. Whether you're a seasoned biohacker or just starting your health optimization journey, this episode is packed with valuable information and actionable tips. So grab your favorite biohacking tools and get ready discussion with Chris Maribel from Novos Labs. So now let's dive in.

Okay, well, welcome to another episode of the Biohacker Blondie podcast. I'm super excited for this episode because we have Chris from Novos Labs and you have a whole health journey and created Novos labs to, I'm sure, from and from inspiration of your past. Welcome to the podcast and please give a little intro how you got into this space, your background, and how how you keep promoting health and longevity. Sure. Well, thank you for having me, Jenny.

Chris Mirabile
It's nice to be here. As you mentioned, my name is Chris Mirabili. I have been interested in health for a very long time. Actually, since I was just twelve years old, I started exercising a regular in the gym. I haven't gone more than a week without working out since I was twelve, other than one exception, which is when I was in high school, I was suddenly diagnosed with a brain tumor.

So at six, had a seizure while on a school trip in New York City. And next thing I know, I was diagnosed with this brain tumor. It's larger than a golf ball above my left ear. And they had to do emergency surgery at a very early age, planning mortality and chronic illness and disease, and wanted to do everything I could to avoid being in this position again. I never wanted to be laying on the hospital bed, wondering if would wake up the next day or not, at least the days, hopefully far out into the future.

So that kind of planted the seed for me to be interested in longevity, but I didn't know it as longevity at the time. At the time, I just thought, I want to be as healthy as I can as possible. It was about a decade ago that I came across a scientific paper in a journal called Cell, and that paper was called the hallmarks of aging. And I came across it because I was very much into health and kind of going versus going to the scientific research and figuring things out for myself. So I would have questions, and then I would try to investigate and find those answers on my own, rather than relying on, like, magazines or podcasters and so on.

And so I came across this paper, and that paper is now considered a seminal paper in the field of longevity medicine. It identified, at the time, nine different biological mechanisms of aging. In other words, what's happening on within our bodies to cause us to age in the first place. And I say nine at the time, because the original authors of that paper, at the ten year anniversary, which was last year, published a second version of that paper, where they added mechanisms. So now there are twelve mechanisms or hallmarks of the aging process.

And when I came across that paper, it was eye opening for me, because I realized, number one, that there is an answer for. I never really even contemplated the question, like, why do we get older? It just seemed like an immutable fact, but never thought that maybe we could have an impact on it. And to that point, the second thing I realized was that aging was malleable. With our lifestyle decisions we make and our environments that we're in, we can speed it up or slow it down.

Contrary to popular opinion, it is not all based on genetics. In fact, only between ten and 30% is based on our genetics. The majority of our aging and how well we age, is based on the decisions that we make. And that was very empowering for me. And that started me on the journey to starting novos.

Jenny Jones
Yeah, I love that all. I think a lot of us in this space have had health issues, and you realize you don't want to get to that point, and you. And you want to encourage others to not get there, right? Like, because you were there, you saw, like, you. You don't take life for granted, you know?

And I've had, like, breathing issues. I've had mold toxicity, and so I never take, like, my breath for advantage, because when you have breathing issues, you know, you're like, oh, my gosh, I do this every day, every, every second. And when you. Yeah, you're like, wow, I need to do something. And when someone has pain, finally.

So you had this. This brain tumor, which also, I interviewed Justin, who started natural stacks, and that was kind of his. Well, because he had a tumor when he was young, and he wanted to get back to optimal brain health. So I have so many questions to ask you, because I want to know if you work on brain optimization. I know, like, we physical in your whole formula, as, you know, doing all these things to prevent aging of the physical body.

But I also want to know things that you might be doing to enhance your brain optimization, right? Because I think we need to focus, like, there's Parkinson's, and then you can also, like, have something that can lead to injury or, you know, these things. So when we think about aging, we have to think about our mental and our physical. Are you focusing on both as well? I'm curious.

Chris Mirabile
Yeah, definitely. So the. The formulation. So, there's two ways to address that question. First is just more on the lifestyle side of how we live our lives and how can we live our lives.

So it's most favorable for our brains and cognition, as well as the rest of our bodies and the other organ systems. The other way to address it is our formulations that we've created at Novos and specifically how they can have a favorable impact on cognition.

Our very first product that we launched, it's called Novos core. This product, it was the first product in the world to address what's known as these twelve mechanisms of aging. My idea was that could address all of these hallmarks simultaneously. Nobody in the world was doing this. Even the most advanced biotech and academic universities, they were really just focusing on one or two of these hallmarks at a time.

And so, to the table was, what if we could use natural ingredients that had been found to have a favorable effect on each of these hallmarks and combine them together in a way that is synergistic? We want to be very mindful of potential diserges, which is negative. We want to do it in a very careful way? But if we do it in the right way, couldn't we potentially have a greater impact on the aging process than focusing only on one or two hallmarks at a time? And the scientists I was consulting at the time, some of whom on our scientific advisory board, world renowned scientists at Harvard Medical School and MIT, the Salk Institute, and so on, it was unanimous agreement that this would be the best way to put a dent in the aging process.

So we created this product ingredients. There are specific ingredients in it that have been found to have favorable effects on our brain health. For example, a commonly known ingredient. This is one that's trending in the health and wellness space. I'll talk about that.

Commonly known is magnesium. And magnesium is needed for thousands of chemical reactions that take place every second in our body. But not only that, it's very good for cognitive health and fantastic for sleep and improving sleep, which then leads cognitive health and so on. Another commonly known ingredient, but also has some longevity benefits, is l theanine, which is also in our formulation, that can help with cognition, with focus, with keeping a steady, calm state of mind. Ingredients that has some fantastic effects on the brain, and it is a lot less known, or at least the supplementation of it is less known, is microdose lithium, which is in our formula.

And so of lithium, because of either exploding batteries on airplanes or because of the psychiatric dose of the pharmaceutical drug, lithium is administered in much larger doses to people with. But we're talking about 100, 100, 5200 times the dosage of a microdose. So our microdose is only 1 day, which is in the neighborhood of what you would get if you were consuming water from fresh cells, because it leaches. Lithium is an element that leaches through the rocks into our water supply. The fish, like the salmon, are absorbing it as well.

So if you're eating that fish, you're getting it. In fact, San Pellegrino water, the water brand, has quite a high level of lithium compared to other, other water brands out there. That's something I never paid attention to. Of all the minerals. Oh, yeah, it's a mineral.

It is a mineral, and it is. It is something that we want a small dosage of. Right? The dose makes the poison, as they say. But we've.

We've largely neglected lithium in modern society. We have all of this filtered water and all these processed foods in our diets. But the New York Times, probably about 1012 years ago, wrote a story about people who were consuming higher levels of lithium in their water supply. Entire communities. And they found communities had lower levels of depression, psychiatric disorder, rape, murder and so on.

There have also been, uh, studies looking at how lithium can have a favorable effect on reducing the risk of Parkinson's and Alzheimer's, uh, and uh, just overall lead to a more balanced mental state. So, uh, there's a lot of potential behind this, this mineral. And um, yeah, it's neglected in novos. That's so interesting because I'm always about minerals, I'm always about electrolytes and, you know, because I don't have a filter, my water, so I could add minerals back in. And that's something I've never, I don't think a lot of these mineral companies are adding that.

Jenny Jones
Is that typical part of like the mineral content? You're, you're right, like, so if, if you were to get, there's like a trace minerals oil that you can purchase that you can bother, uh, that actually has lithium in it. Uh, has I think, one and a half or two milligrams of lithium per day. Right? So you would be getting it from that.

Chris Mirabile
Depending on the brand and so on. Some brands might be intentionally trying to eliminate it, uh, because associated with it, people just oftentimes will just immediately react to the word lithium and think something negative because they associate it, again with bipolar disorder. But if you look at the research, we have tons of it on our website. If you go to and you scroll down to the bottom, there's a table with hundreds of scientific studies that support the inclusion of each and every one of our ingredients in our formula. But if you search for the word lithium, you can see a lot of scientific studies for it.

Your own research on pubmed, or look for articles that have been written about the topic of lithium microdose specifically and its health benefits. And it's really impressive. I love how there's just so much research behind it because a lot of the supplement industry is very corrupt. And so it's like, is this stuff even working? Is the quality, is the quantity even in the supplement, it's a huge space that is very, you don't really know.

Jenny Jones
It's like, who do you trust? Who do you, you know? And so it's great. Like, I know, like timeline nutrition does a lot of research behind their supplement, which is so important. So you guys have done a ton of research on your supplement stat.

I want to know, so what can you tell the audience what your hallmarks of aging are? I know, like for me, like sir tunes or all these different parts of like, aging. So your telomeres but can you kind of go through? I don't know if you have them all memorized.

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Chris Mirabile
Sure. So I do want to echo your original point, which is that what most people don't realize is that 99% of supplement companies out there, just marketing companies, they position themselves as health companies and they do all of the branding and so on, but it's really just about positioning themselves in a sales emarketing way to get someone to purchase something, but really doing scientific research to validate their products and to prove out that the product does what they say they do. There are very, very few companies out there that actually do that. And there's very big out there that is in the greens space that everyone purchases and uses as if this is a magic formula. I know, but there's really no science behind it's behind it.

Right. So I don't like name calling, so I'll keep, you know, I won't, I won't mention them by name, but there's a lot, a lot of hype around these types of companies, but there's really no science behind it. And we're focused on from core of our business is PhDs, MDs, bioinformaticians. We do original research, we make new discoveries and we create first of their, their kind formulations. I mean, there are companies out there now trying to for the twelve hallmarks of aging that we did file for patents on our formulation and many different versions of our formulation.

So they'll have a hard time actually doing it successfully. But nonetheless, we are taking the lead in this field. I'm inspired by biotech industry. There are some good things about them, also some bad things about them, but the good things are how intense they are with their research and proving things out. Unfortunately, that hasn't made its way over to supplements.

Companies feel like they can't have enough ip protection behind what they produce, so they're not as financially incentivized. They're also not getting insurers to pay for their products, so they're not as financially incentivized to put as much R and D money into. But I have a different vision for how we can execute on this and make very high quality supplements and take a page out of that biotech book while still being in the supplement space. So when did Novos come out? One quick question though.

Jenny Jones
When did Novos come out? When did she, when did. I had the idea for Novos and established the business in 2018. And then for the next three years, I spent scientists and putting together the initial formulation and R and D versions of the formulation. And we had consumer test groups that were testing it out, reporting any side effects and so on.

Chris Mirabile
And then eventually in 21, we launched commercially for sale our first products. Okay, so it's pretty recent, it's pretty new for the supplement. Yeah, about three years or so of R and D and then about three years since we've been shipped. Have you ever worked with David Sinclair or anything?

Jenny Jones
He's big on resveratrol. And you don't have resveratrol in your supplements. Some controversy with resveratrol, so. And I know you have, I don't know how to say, spysetin Fyzetin, which is also really known as to help promote longevity. So, yeah, can, we'll get back to the things of aging.

Can you go over those since you're probably more of an expert than I am sure. Well, to your question about Sinclair and resveratrol and so on. Yeah. When I said that, I consulted with scientists the concept and got validation from any scientists. One of those scientists was David Sinclair.

Chris Mirabile
I met with him at his lab at Harvard and shared with him the vision for the business and our original formulation idea and so on. But we've evolved a lot since then. No, I don't currently work with him. I work with his counterparts and peers at Harvard, like doctor George Church, who invented genome sequencing in 1984. He's a whale of a biologist.

Resveratrol, I don't believe it. I never have. I don't think that it has any longevity effects. It could potentially do something for someone who's obese, maybe in theory, the scientific research that has been done and hasn't really been well replicated at all, but let's just assume that it is legit, high quality research. It was really done in obese mice and that's where we saw a positive effect.

It wasn't found in regular, healthy mice. I think it has a very potential use, and that wouldn't make it a longevity drug. It would make it some, you know, substance suitable for. For someone who's obese and metabolically deranged rather than a otherwise healthy person. Yeah.

So the twelve hallmarks, I don't want to miss these. We keep going on these sidetracks. So. So I can give a brief explanation of each of them, too, I'm sure, for your listeners. Yeah.

The first one, no particular order, but the first one is mitochondrial dysfunction. So our mitochondria, the power plants of our cells, they take the food that we eat, the carbs, the fat, and to some degree, the protein, absorb that and then convert it into ATP, the energy currency of our cells, and enable our muscles to move and our heart to beat and our brains to think, essentially. And as we age, we have fewer of those mitochondria. The ones that we do have start to get damaged, and they don't perform quite as well. So essentially, our cells are less efficient with the food that they're getting.

And the result is that the cells can't really perform as well as they otherwise would. And then, as you can imagine, into the organ not performing quite as well as it other otherwise would. So that's the first hallmark of aging. The second one is cellular senescence. So people are starting to talk about senescence now on social media.

Oftentimes it's zombie cells. So these zombie cells are, as a cell gets old or if the cell becomes cancerous, the body has this mechanism where it can actually turn it senescent. So that's a good thing if it becomes senescent. The bad thing is that these cells release inflammatory molecules. It's called a sasp sasp.

And these inflammatory molecules can then impact nearby cells and cause them damaged and eventually turn senescent as well. And so we see the number of senescent cells going up exponentially as you age. And it's one of the. Not the only reason, but one of the reasons why our skin and its health declines with age and wrinkles to form as we get older is because of a higher level of senescent cells. And you don't have spermidine inovos?

No, we don't, and for a good reason. You want to hear my controversial answer to that? Yeah. We spent 18 months working on a product that would contain spermidine in it as its star ingredient and spent a lot of money on it. And a lot of time.

And we ended up abandoning. The reason being that it started with a scientific paper that was published that looked at spermidine absorption in humans and essentially found that people who were in the study who were, had no increases in spermidine in their blood, serum or cells. So, in other words, and this was measured at multiple time points, like, within a few minutes of consuming it. And I forgot exact time, it's later and then 60 minutes later, and there was no increase whatsoever. And so the logical conclusion from that, and the way a scientist would look at this, is that it's being broken down in the gut, it's not being orally absorbed.

We then took that and we looked at all of the other scientific studies to see if there are any other studies that indicated that maybe there's something wrong with this study, but there's no studies out there that we feel confident in showing is actually absorbed orally. Now, we're open minded as a scientific organization to be proven wrong. If there's a great study that comes out that shows that it is definitively absorbed orally, we're open minded to that, but we have yet to know. Our position currently is that spermidine is not absorbed in the gut when you consume it orally. You're not actually getting the benefits that you see in animal studies.

Um, or that you would get if it was injected, um, or that you get from your body naturally producing the spermidine, but actually consuming it orally is not going to do anything for you. Wow. Okay. Okay. That's why we don't have it in our format.

Jenny Jones
I just thought of that. So I don't actually take it. And I didn't difference when I took it. So I don't know. That's why I took it for a bit and I stopped taking it.

That's why I'm curious. I would. Yeah, I would love to say it works because then the, you know, six figures that we invested into produce, we could actually bring to market and sell it. Right. It's in our financial interest for spermadine to work.

Chris Mirabile
Like, we have that financial bias for it to work. We have nothing against it. We're agnostic about ingredients. We want to bring whatever works to the market. But as I said before, we're not a marketing organization.

We have a marketing team, but we're not a marketing organization. We're a biotech organization with a marketing arm. And so that biotech organization makes the final call on what we produce, not the business team. It's the biotech team that decides if. We'Re going to love.

Jenny Jones
All right, back to the twelve hallmarks. Okay, so the next one, loss of proteostasis. So proteins are signaling molecules, right? So that's essentially what our DNA is for. DNA then leads to transcriptome to then lead to proteins being produced, and these proteins in a certain way, and then they are picked up by certain cells as signals to behave a certain way to trigger the cell to do something.

Chris Mirabile
And as we age, these proteins might not fold, folded properly, it's not actually going to function properly. These proteins can start to accumulate inside and outside of the cells. By doing so, it then interferes with proper functioning. So this happens increasingly as we get older. It's almost like if you don't take out the trash from your home, eventually it's going to start piling up.

And that's what happens over the years as we age. For theostasis, next is altered intracellular communication. Our cells, they, they are subject to an increasingly hostile environment as we get older. You know, part of that is proteose, part of it is inflammaging, which we'll talk about in a few minutes. That's another hallmark of aging.

Some of it is from senescent cells and dysfunctional stem cells and so on. But this prevents the cells from being able to communicate with each other as well. There are these vast networks of cells that are communicating with each other. It's like a whole community of cells that have this innate intelligence to them. And as we get older, our body isn't as well the cells to be able to communicate with each other.

And when we're not communicating, as we know, in relationships, things start to fall apart. The same thing happens within our bodies. Yeah. Next is genomic instability. So genomic instability, also known as DNA damage.

This is a commonly known one. Right. Like we hear, put on sunblock because you don't want to get some burns, you don't want DNA damage. DNA damage and some burns can lead to skin wrinkling, for example, aging of the skin, skin cancer. When you have genomic instability, DNA damage, you have a higher chance of cancer.

Right? Because those DNA mutations can then lead to. So we want to be able to protect ourselves and reduce the amount of. DNA mutations, basically with antioxidants, toxins, doing all these things to reduce DNA damage. Yes, generally speaking, yes.

But antioxidants, it's complicated because you can actually overdo the antioxidants and you can actually shorten lifespan if you have too many antioxidants. And sometimes antioxidants can actually run. So, for example, if you exercise and then you take a large dose of vitamin C and or vitamin E after your workout, you're actually going to counteract a lot of the benefits from your workout. Because when you exercise.

Jenny Jones
Before, is that okay? Yeah, you probably don't want to. To be honest. You probably don't want. Do I take vitamin C?

Chris Mirabile
Space it out as much as you can. Like, if you work your vitamin C, like at dinner time or something. Here's the reason. So when you exercise, your body is actually. You're becoming inflamed from exercise.

Jenny Jones
Yeah, yeah. It's a stressor and your body is. And that inflammation then leads to these molecules, these inflammatory molecules that normally we think inflammatory molecules, these are bad, but actually for exercise, these are signaling molecules, according to this idea of cells communicating with each other. And the proteins and the signals, these signals are going to tell the body to come back stronger and more resilient. So in other words, build more muscle, for example, intercepting them with vitamin C and vitamin E.

Chris Mirabile
It's actually been shown in human studies that those consuming high doses of c and e around a workout actually have less gains over the course of, you know, a few. So curious. I mean, I don't take a multi supplement. I kind of just do my own formulations because I like to choose what, you know, based off of my blood work or whatever is going on. So would you recommend my vitamin?

Jenny Jones
Because then, you know, vitamin C or something in these multis or, you know, that people take in the morning. Yeah. The complications of being healthy. Yeah. Complicated.

Chris Mirabile
But at the same time, you can also make it simple. Like, I've also been at the point where I was creating my own multivitamin stack of, like, each and every individual nutrient. And I did that for a few years. And eventually I decided to just go single very high quality multivitamin. And here's the logic behind it.

You've got fat soluble vitamins and you've got lipid soluble vitamins also. One other point to raise is that scientific study, which looks at nutrient intakes and health outcomes, among other things, has found that the vast majority of people, almost 100% of people, have at least one nutrient inadequacy, whether or magnesium or coal or vitamin E or vitamin K or vitamin D and so on. Right? So most of us are running multiple inadequacies, even if we eat healthy diets and live healthy lifestyles. Keeping all of that in mind, water soluble vitamins, practically all of them, you can go with very high doses.

And it's not going to cause harm, you'll just pee it out. There's an exception with one or two B vitamins, but you would still have to go super high with them, be a problem. And then fat soluble vitamins, they can accumulate in the body. That's like vitamin D and vitamin K and vitamin E, vitamin A. But as long as you're not taking very high levels and maybe once a year you get a test for your vitamin D levels, you're also not going to overdose on them.

So my perspective is I'm going to take a moderately dosed, very high quality multiple to cover all of the bases. I am almost definitely not going to overdose on any of these fat or water soluble ingredients. And I'm going to make up for any inadequacies or deficiencies that I might not otherwise be aware. Blood tests, they're helpful, but they're not definitive. For example, you might have very high levels of b twelve in your blood and think, oh, I've got tons of b twelve, that's great.

But little do you know, the reason you have high levels of b twelve in your blood is because cofactor to get that b twelve into your cells. So you're getting enough b twelve, yes. But you're running a deficiency in some other nutrient so that your body can actually utilize that b twelve. And so it's complicated. I try to figure it out.

If you could instead just do a small dose on all of the nutrients so that you make sure you have all of your bases covered. Yeah, I do love that. I think sometimes based off of diets, like I know vegans or vegetarians, they might iron. So I think some type of blood work can be an eye opener or like even your thyroid is low, like t three or something. And it's like, oh, definitely.

Jenny Jones
I'm really low in selenium, I'm really low, you know, in iodine or something. And I really need to up my intake two months to get my levels back up, you know. So I think doing some blood work is amazing to just, I like, keep people aware of what their body might be extremely deficient in or way over the top. And then most part though, it's just like those little, you know, a little bit higher, a little bit lower than that. Multi can be beneficial.

So you take a multi and Novos every day. Is that your go to multi, novos plus k two supplement d three k two supplement. Fish oil. High quality fish oil with low toe toxic. Could you say which fish oil?

Chris Mirabile
Uh, you know, the typical one. Nordic naturals. You know, there's. Okay, yeah, I know. You hear there's corruption there and not with that one, but just fish oils.

Jenny Jones
Are they oxidized? Do they really work? I mean, there's just so much of this, like, you know, what's good, what's bad, you know, but the fish. A little sketchy on. Yeah, you know.

Chris Mirabile
Well, so there's, there's a few things to keep in mind and for your audience to keep in mind. Number one is that there's always going to be some kind of controversial study that comes out that the press eats up and really wants to says, fish oil is not good for you. It actually makes you die younger or something. Right. But then you need to take this in context of all of the other established research prior to that one single study.

And you also need to study rather than what the press is saying about it. Right. Because the press is usually misinterpreting it or they get a quote from someone who is underqualified to actually talk about it. Oftentimes it's like, you know, it might be, say, a dietitian or even a. But oftentimes it's actually better to talk to a PhD scientist, researcher who is intimately familiar with, like they're an expert specifically on fish oil.

They're going to know more about it than, say, you know, a random medical doctor is going to know. So oftentimes they're quoting the wrong people. And so you need to look at the, all of the research behind it and determine whether you're going to believe that one single study, not to mention there are specific factors that can, when it comes to fish oil, for example, that can have a significant impact on the outcome. As I mentioned before, toe tox. The total oxidation basically is your fish oil has it oxidized, in which case you're actually swallowing a poisonous substance, something that can cause damage to our bodies.

You want to make sure it's a very high quality new fish oil. I keep mine in the refrigerator and I also try to eat fatty fish, more so than I supplement. But, you know, if I'm going an extended period without the fish, then I'll take the fish oil. What do you think of olive oil? I know Brian Johnson's really big on.

Jenny Jones
Do you also do that? Olive oil is great. It has polyphenols in it. It has fantastic health outcomes from consuming olive oil. I don't think you need to, you.

Know, get a specific health cures all. No, it's not, it's not, it's not a cure all by, by any means, uh, is it. Is it something that is ideal to integrate into your diet as opposed to other types of fats? Yes. To, you know, people have really pushed coconut oil and butter and lard from, you know, grass fed meats or something.

Chris Mirabile
Right. Like, overall dairy, olive oil. Yeah, I boil. So do you take that? Take a shot of it?

Jenny Jones
Have you gone on. No, I do have it. I do consume it daily, but I don't take a shot of it. No, I season my food with it. Like, I'll have, you know, a bowl of vegetables and throw in, whether it be some fish or chicken or something like that.

Chris Mirabile
And then I'll take some olive oil and drizzle it on top. You have to try his. Okay, I have a bottle of his olive oil. It is really good. It's olive oil I bought, surprisingly, but I don't think it's the cure all.

Jenny Jones
But I do have it, and I don't take shots daily.

No.

Chris Mirabile
I like food. I like, I don't want to waste my calories on taking a shot of olive oil, but if I combine it with a food, then it tastes good. Like a good salad. Yeah. So you guys were involved in this study with the 55 year old woman versed her age better than Brian Johnson.

Jenny Jones
Right? So was part of this study, or did she find, you find Novos and just start taking it? I would love to talk about that. I think that's super awesome that you mean a year or. I know it goes to a lot of research of his, not just his biohacking health, but I'm curious, did she just take that and then a multi.

And then. Yeah. How did you guys collab and connect? We do a lot of research with that as well. Yeah.

Chris Mirabile
So, first of all, she's not the only customer of ours who have outperformed Brian Johnson. Okay. We haven't. Like. So, first of all, on the rejuvenation of this official leaderboard, we've got multiple customers that have outperformed him from just spending, you know, less than $100 a month on our product.

You know, I can't. I can't name specific people, but we've got dozens of people taking our biological aged clock and our Novos customers who have outperformed him as well. So, officially, on that leaderboard, there's, I think, two or three people who have outperformed him. On the top ten list. We've got dozens of people who have outperformed him.

Jenny Jones
Are you on that list? In terms of my personal performance, I think I have. So, for the specific epigenetic test. His best score is my score, so we're equal. But I've also done many other biological age tests that I don't think he's been doing recently.

Chris Mirabile
But when he used to do them, I had better scores than him on all of those as well. I know. The whole testing I've heard, too, is where you might have to take it even three times. There's different types of ways of doing the biological age test.

Specifically for the rejuvenation Olympics, they have a requirement that you take the test three times. And although we have dozens of customers that would qualify, they haven't taken it three times. They've taken it one or two times. And so that's why they haven't been submitted to it. But that's just a rule that they've been stated that that's not, you know, there's no, like, irement for that.

That's just. Yeah, it's. With the true age. It's. No, not true age.

It's true. Diagnostic lab. Yeah. Now, true age was an algorithm is not used for the rejuvenation Olympics. The algorithm that's used for the rejuvenation Olympics is the do need in pace clock, which was produced by Columbia and Duke University researchers.

And that's the clock that we offer in our epigenetic age. So we sell it. Okay. But it's not our algorithm. We license it from Columbia and Duke, and we don't run the tests ourselves.

It's a third party entity that's running the analysis on our customers. So roll over the outputs. There's no conflict of interest in our results that are being reported. Interesting. Yeah.

Jenny Jones
It's not your own novos, it's your third party. Okay. And because I know there's also. What exactly are these tags? Because I know there's like.

Isn't like glycogen. There's like, a few different ways to test glycogen. Glycans. Glycans. I think you're talking about glycans.

Yeah. Yeah. So there's different ways to kind of test your biological age. It's hard to test. Are great to say, hey, something might be going on.

Are you doing better than you did six months ago? Is it a true all? I'm, you know, 15 years younger? I don't really think so. I think there's so many ways to put longevity in a whole.

There's so many factors that contribute. So I think it's hard to say, like, this one test is going to make you, you know, you're 15 years younger, you know, but I think it's great for out of eight people. So I want to know. So all your. All the things you're doing.

So you go into exercise. What did you do before novos? How did you, like, are you into this? Is this part of your background? I can answer that question, but if you don't mind, I'd love to just talk a little bit about biological age clocks, since you brought it up, and I think there's a lot, we need to bring a lot of clarity to the space, because there are.

Chris Mirabile
Some are far superior than other clocks, and I think that people just hear the word biological age, and they treat it as a blanket term to apply to everything, and it shouldn't be taken that way. Yeah. So if you're okay with that, it. Just spends even, like, the function, health. I know they have a biological age, and it's just based off of some numbers of your labs, you know?

Jenny Jones
Yeah, yeah, yeah. So it's all different. So I'd love to know. All right, so. So what is trying to measure?

Chris Mirabile
It's trying to measure, essentially, how old we are biologically, which can differ from how old we are chronologically. For example, we all know the 50 year old who looks like they're 65, and we know the 50 year old who looks like they're 40. And the energy of a 40 year old, the skin of a 40 year old, the vibrance, and then the 65 year old looks like. Or the 40 year old that looks 65 is somebody. Or 50 year old that looks 65 is somebody who should be in a hospital or something.

Right? Like, they're just. And this is because we can age at different rates, and our lifestyle is really determining how fast and slow we're going to age, for the most part, far more than genetics. So biological age is what our morbidity risk is. So our chances of getting a disease of, like, heart disease and cancer and diabetes and Alzheimer's and so on.

Mortality risk, because every year, there is a chance that you will pass away. That goes up exponentially as we get older. And our quality of life metrics, ideally, is being tracked as well. So that's like, our gait speed and our grip strength and our ability to stand up from a seated position without assistance and so on. Thats essentially what we want to capture with biological age.

Now, there are different ways to try to measure this. Some people will just look at one marker, like vo two max, the maximum oxygen volume our bodies can consume while and say, my biological age is that of a 20 year old, because my vo two max is that of the average 20 year old. Well, no, your biological age is not that of a 20 year old. Your vo two max is that of a 20 year old than saying, you overall, as a person, are biologically 20. Right.

And so there's a lot of confusion there, first of all. And a lot of people are making erroneous statements about that. So now, if the goal is instead to figure out how old organism as a whole body, then the question is, what's the best way to do it? You mentioned glycans, for example. There's a test called Glycan age.

I would say that this is probably better suited for, like, urine and maybe immune system age, but not full body aging. So that's just one aspect of our body. And, yes, our immune system is very important, and it might be worthwhile for you to get that test done if you're curious about that aspect of aging, but it's not whole. So then the question is, what is the best way to measure it? And there's something called the multiome.

And the multiome composes your genome, your epigenome, your transcriptome, proteom, metabolome, and so on. I won't get into the complexity of all of that, but the point is that the one to focus on is the epigenome. So your epigenome is, imagine a layer that sits on top of your genes, and it determines which genes are turned on or off. So it's almost like these are your genes, and then which keys are being played is your epigenome. And as we age, different genes turn on or off that should or should not be turned on or off.

And there are patterns. And so scientists have been able to build algorithms to detect these patterns. And these patterns are associated with disease, with mortality, with quality of life, with chronological age, and so on. And based on this, approximate to a high degree of accuracy, how old someone is biologically. So epigenetic tests, number one, are the best form of biological age tests.

But even within epigenetic tests, there are three different generations of tests. Tests came out about a decade ago. Researcher in California named Steve Horvath invented them. And these were trained on chronological age. So they were trying to look at your epigenome and predict how old you are, Jenny.

Old your passport says you are. And they got relatively accurate with that, especially when applied to a population of people. It was within a very high degree of accuracy, more so than when it's applied to only one single might have more, might not be as accurate. They might overestimate or underestimate. They then realize that it's more important to predict how old you are biologically rather than chronologically.

And that's when second generation tests came in. And these are tests and the pheno age test, the latest generation of tests are third generation tests. And this is where what I mentioned before, the do need and pace clock comes in that we license from Columbia and Duke universities. This actually tells you rate of aging, how fast or slow you're aging at this point in time. So it's your trajectory and this is most actionable.

So the lifestyle decisions you make within three months, you're going to see that impact your trajectory or your. So I have some exciting news. My book Biohack for life is available on Amazon. This is your ultimate functional medicine guidebook packed with everything you need to optimize your health and well being. In biology, I cover essential topics like lab work and detox, providing you with the best supplementation recommendations to support your health journey.

Jenny Jones
But that's not all. This guidebook also dives into the newest and most advanced biohacks, including peptides, ozone therapy, hyperbaric oxygen therapy, continuous glucose monitors and powerful interventions like rapamycin and metformin and so much more. Whether you're a seasoned biohacker or just starting out, life has something for everyone. It's designed to empower you with the knowledge and tools to take control of your health and live your best life. So grab your copy today on Amazon and start your journey towards optimal health.

Chris Mirabile
So it's empowering and it's something that we can actually practically use to see. Oh, by taking that spermaidine that you're just, you know, not even absorbing and you take a high dose of it for three months and then you take a test again, you'll see that your b not been favorably impacted and you can say, all right, I'm going to throw this spermatine out now. Whereas maybe you change your sleep routine or your exercise routine or your diet and all of these things, you take the test again and you see your age has improved. Your point about our customers like Julie Gibson Clark, who is ranked number two in the world. Not only did she outdo Brian Johnson, but she's ranked number two in the world for her results.

This is how we measured it. I also saw that she was like, wow, she makes sure she gets her sleep, which I'm really adamant about sleep right now because I'm not. Yeah, it's always difficult for people. You know, people want to do so much, they want to go out they want to work or whatever. This really, I think, has a huge impact on our overall health and longevity.

It definitely does. I sleep at least 8 hours. You do? Wow. Wow.

Jenny Jones
I'm.

Chris Mirabile
I mean, I would love to be able to get seven, but I don't function at the highest level. If I'm getting seven, I can tell the difference in the quality of my work and my exercise performance as well. If I get half hours of sleep versus if I get seven, I can go a day or two at seven. But if I go beyond that, everything declines. Wow.

Jenny Jones
So you have, do you do like, the blinds and the mask and mouth tape for 8 hours of sleep? Everything but the mouth table? I do. All right. So.

Chris Mirabile
So first I have hue light bulbs installed across my home. So at about 08:00 I'll switch the color from to yellow and then eventually orange. And then they turn red about 30 minutes before bedtime. It looks like, you know, Amsterdam's red light, the red light district. If I hold a lot, it helps so much for, for me.

Like when I put my head down on the pillow, I can fall asleep within five to seven minutes according to my oura ring. Like, I very quickly fall asleep. When I fall asleep, I have earplugs. They use earplugs. You learn how to put them in your ear properly because most people just try to shove them in.

There's actually YouTube videos you can watch to see how you do it properly. But when you do it right, you get the seal and it blocks out everything. And, uh, you know, oftentimes she's walking around or making noise and I won't hear it unless she barks. I won't hear it. If I have my earplugs in, which is great, then I have a sleep mask on and, uh, they're very cold.

But then have a heavy blanket. So my body while I'm sleeping, it can determine how much of the, of the blanket it wants. And, uh, that's pretty much it. And do you eat? Do you stop eating?

05:00 no, 11:00 a.m. i stop eating about. I stopped eating like 3 hours before. 4 hours. Three to 4 hours before bedtime.

Jenny Jones
Okay. Wow, that's pretty amazing. I don't know. Like, a lot of people have a hard time sleeping, especially. Yeah.

I mean, there's so many things that go into a good night's sleep. And then the oura ring just keeps you a really accountable, hey, I need to sleep more because I thought before I got the our ring, I thought I was sleeping more than I was. Yeah, really hard time sleeping, and I spent a lot of time obsessing over it, and I fixed it. But one of the issues that I had was, first of all, I wasn't eating enough food, I wasn't getting enough. I was experimenting.

Chris Mirabile
This is going back like ten years ago now, when I was about 30 years old, I started experimenting with a ketogenic diet. And I found myself not needing to eat as much and being able to fast much longer and up at 03:00 a.m. every night. And I couldn't figure it out, and I couldn't sleep. I couldn't get back to sleep.

And I would take like, a teaspoon of honey, and that might help a little bit for me to get back to sleep, but it turned out I was just calorically starved. I wasn't calories. And that's enough for your body to produce cortisol, because your brain needs, needs sugar. And so this process called gluconeogenesis, your body is going to produce new glucose. To do so, it needs cortisol to kick off the process.

And cortisol is what your body produces in the morning to wake you up. Well, if your body is producing it at 03:00 a.m. so that your brain has enough glucose, its going to wake you up also. And so that was a big component of, of poor sleep. There are other things, my friend, just keto as well.

Jenny Jones
And she, that's why she had to stop, because she was like, I couldn't sleep, so she was realizing how, like, eating just me carnivore lifestyle is like interrupting her sleep. So she actually switched. Well, so what I was just going to say with the keto diet, another point to make is that when you have carbohydrates, it can also lead to lower levels of serotonin, and serotonin converts to melatonin. And melatonin is the sleep hormone. And so there's potentially disruptions and more so for females related with keto diets versus males.

Chris Mirabile
But even I as a male, felt the effects of the keto diet. Now, I can go in and out of keto every so often, whether I fast or I selectively do a keto diet for a couple of weeks, but I can't do it for time before I start feeling negative effects from it. That's a good point of the serotonin and the melatonin. I even think of that connection. So what is your diet like?

Jenny Jones
Is are you just kind of in the middle range? Fruits, vegetables, just kind of a little bit whole foods diet, right? It's a whole foods diet. I actually follow the Novos longevity diet. So the Novos longevity diet is 90% a mediterranean style diet.

Chris Mirabile
Medicaid diet is proven in study after study to be the best for long term health outcomes. Even a more recent study looked at the epigenetic signatures. So these biological age clocks of different diets, like the Ornish diet and vegan, and the mediterranean diet performed the best. So I follow that. And that includes lots of vegetables, rather than a lot of grains, like the mediterranean diet has, with more mushrooms, cruciferous vegetables, legumes, beans, stuff like that.

I still do get some grains, but there'll be, like, quinoa, sometimes some wild rice, things like that. But I try to avoid the fast at all. Like, do you have a time frame to eat? Yeah, I do. Time restrictive feeding.

I'll eat typically between and seven, approximately. Okay. And I haven't done it for a while, but I was also in the habit of doing, like, 24 hours fast, like once every few weeks, like, maybe like Thursday dinner time until Friday dinner time, and then I would do three to six months. I would do it a 48 to 72 hours fast. Haven't really been doing that for more than a year now, but it's something I used to.

No, no. Okay. So I don't. I could go on and not ask you so many questions, because I love this space and everything, but I don't know if you want to go over just the ingredients really quick in your supplement and talk about how they kind of can interact. I know, like, even there's, like, hyaluronic acid.

Jenny Jones
Is that for skin? Is that for our body? There's, like, certain ingredients where I'm like, why were those chosen? You know? Sure.

Chris Mirabile
So this is what the product looks like, at least the daily serving. So it comes in a box, and so you get 30 servings per box, and you tear it open, you put it into your water. We have an orange flavored one that's naturally flavored and sweetened with stevia, and then we have an unflavored version that has no. So the unflavored is best to mix with, like, a smoothie or a juice or yogurt, because it does have a little bit of an herbal flavor to it. Um, and the ingredients, I'll read through them quickly.

Um, we've got lithium, as I mentioned before. We have an ingredient called terrastil bean, which is found in blueberries. This is a cousin to resveratrol, but this is actually a lot more effective than resveratrol because it has higher oral bioavailability life, and it has methyl groups attached to it. Um, so overall, it has better health, um, effects than, um, resveratrol. We have organic ginger root extract, uh, which is standardized to 2%.

Ginger has some amazing health benefits to it. We have physetin, which you mentioned earlier. So physetin is found in strawberries. It would take about a hundred strawberries a day to get the dosage that we have in our formula. And phycytin can have a effect on senescent cells, which we talked about earlier, these zombie cells, hyaluronic acid, like you mentioned.

So why do we have hyaluronic acid? Well, there's two reasons. The primary reason is not what most people would think. It's because hyaluronic acid can called acetyl glucosamine. This is different than glucosamine sulfate, which we also have in our formula.

Acetyl glucosamine is a completely different molecule. And acetyl glucosamine has been found to extend lifespan in multiple different.

Now, a second reason, an added benefit of the hyaluronic acid, the oral form, is that this can improve skin health and also joint lubrication. So our bodies produce hyaluronic acid. It's what? But starting at about 20 years old, it decreases significantly with every year. And so that's one of the reasons it's not the only ingredient in our formula, but it's one of the ingredients that leads to people after using our product to two months, they know there's improvements in complexion and skin health.

We actually did a pilot study where we found users of our formula after six months had on average, 22% improvement in skin firm, as measured by a device called an indentometer, which is a professional skin, skin taking every day interests of yours. So I'll talk about other ingredients that. Can help with skin. So there's also glycine. Glycine is an amino acid.

It's found in collagen. We get very low levels of it now in our food supply, typically, but it can also help with sleep and for supporting the collagen synthesis in our skin. Glucosamine sulfate can also help to build the skin matrix. So those plus vitamin c, we have a small dosage of vitamin c, 100 milligrams. But combining all of those together can really help with.

With the skin. We have l theanine I mentioned earlier, which is really great for focus, concentration, calmness. But it's also extended lifespan every ingredient in here, by the way, has been shown in at least one animal study, sometimes multiple, to extend lifespan. Rhodiola rosea. This is an herb that can.

It's an adaptogenic herb, so it can help you deal with stressors. It can help you focus. It can help to improve energy levels in the morning. It can help to improve sleep if taken in the evening. I mentioned glucosamine sulfate, calcium alpha ketoglutarate, a full ingredient for longevity.

It has significant effects on epigenetics and on our biological age results. And specifically, the calcium form is important when it comes to longevity, as opposed to, there are other forms like arginine, so on. But it's the calcium form that you want for longevity. Malate, which is found in apples and also known as malic acid malate has favorable effects on long term health and on longevity. And let's see what else.

And then magnesium, which is being provided through the magnesium malate. So that means that the magnesium and the malate molecules are combined. They're one single. But when we absorb it, we break them apart, and you get the malate and the magnesium. And so this contains 304 milligrams of magnesium, 72% of your daily value.

So between this and then eating a, you're getting all of the magnesium that you need. Wow, that's such an interesting stack. I don't know, like, you just hear all these different, but that's, like, different than what you typically hear, like, say with resveratrol or spermidine or certain ones. Those aren't really common ones that you hear as much, but it makes sense. And do you recommend taking this in.

Jenny Jones
The morning or when do you take your. When do you take it? It depends. So we have customers who take it in the morning. I actually split up my dose.

Chris Mirabile
I have half of it with my lunch, and then I have the other. Half of my dinner. I like to do it because I like the taste of it and I like to kind of, you know, I look forward to drinking it with my meal. So those two different meals, but also certain ingredients, is probably better for you to have it over a longer period of time. Like calcium alpha ketoglyberate.

It's probably better that you. You have it spread out a little bit out. So with, like, vitamins to do it. Right, because it's just, I've heard too, like, for immunity, like, if you, you know, if you maybe you're sick or something, to take vitamin C throughout the day because it's water soluble. So it's just kind of want to keep taking it.

Jenny Jones
So. Yeah, something I've heard in that sense, for that case. Yeah, that, that makes sense to take it throughout the day, definitely. Okay. And then someone asked about your skincare routine.

Do you do, what do you do for your skin? Do you do anything for the outside? Do you have like a little hair, hair routine or do you just have naturally good skin and hair? No, no. I had tons of acne growing up, like more so than anyone in high school, probably.

Chris Mirabile
So I wasn't blessed. But yeah, what do I do? So obviously I take novoscore novos vital as well, which is our newest product. That's a whole other category of product. But then topically, let's see, I wear on my face, on my body.

Different story. I'm okay with getting a little bit of the uv rays and producing the vitamin D endogenously. And so if I go for a run for less than an hour, I'm okay with some of the uv. Also because I live in Florida, I'm exposed to the sun. My body has adapted to it.

I have a lot of carotenoids in my diet. I have very high levels of skin carotenoids. I've had it tested, uh, which can help to, from the damage of uv rays and so on. And I'm not spending excessive periods of time in the sun. If I was, I would definitely wear sunblock on the rest of my body.

But my face, okay. I always protect it for the sake of uh, reducing the chances of wrinkles. Um.

Jenny Jones
Do you use tretinoin and retinol? I, I use tretinoin. Uh, so yeah I use um, 0.05% retin a everyday, about five nights a week, on the weekends. And I don't use it on the weekends, but I use it on the weekdays. I use a serum.

Chris Mirabile
I've experimented with different kinds. I like the ordinary copper buffet. It's got a number of peptides in it, including ghkCu, which is the copper peptide. Yeah, I love. And then I've experimented with all different types of skin creams.

Everything from skinceuticals and blogique Rocher, the higher end of the price spectrum to some like ordinary brands. And they have a higher end product called Niod. I've tried their products so just experimented with those. But for the most part it's really the Trent Owen and just keeping the skin moisturized. And to some degree maybe the peptides help as well.

Jenny Jones
Yeah. Okay, another quick question. Have you gone anything into stem cells, ozone as well to like extend your longevity? Have you played with any of like peptides? Any of those?

Chris Mirabile
I tend to be a little bit more practical minded and pragmatic about all of these types. I've tried these things out and experimented with them here and there. Like maybe ten years ago before peptides were what they are now. I've tried a couple of them like for example BPC and I was having some permeable gut issues and so I tried that. The oral administration of it and what else?

No, I don't do ozone. I've done hyperbaric oxygen chamber but I don't. It's more like a. It's more like let me experiment. Let me give it a try.

Let me see what all the hype is about. But I think for the most part, like when you look at someone like this, right? It's like you, if you look at Julie Gibson Clark's results, if you look at Amy Hartheson like these are people who are at the top of the charts for their, their pace of aging and just overall health. 99% of it. 95%.

You know some crazy is based on your sleep, your diet, your activity levels and your recovery, your psychology, your relationships, your supplements and to some degree potentially prescription. I get into that or not, it's a different story. But prescriptions like metformin, arapamycin, like that, that's, that's basically gonna do practically everything for you. Now. You can experiment with other things.

Like for example I do have the red light near infrared like face mask thing that I have tried but like I'm inconsistent with it and I haven't really seen that much of a difference from using it. So. Yeah, I bet you tread knowing is. Doing or more than the red light therapy is. That's just my opinion.

I'm not basing this on scientific studies but that's my opinion at least for my own personal. Okay. Okay. Yeah. Just all these questions.

Jenny Jones
You know, there's so many things in this industry. What's really making the biggest impact? You know, I think a lot of people are like I don't have time to do those 5000 things. I don't have the money to do those 5000 things. So yeah, we always want to be like what is working the best?

You know, I guess the less amount of time. Yeah, I mean I'll say, I'll say that like everyone is really tempted to try to find some sort of technology that's like novel and cool and sexy and exciting. What I would suggest is that people focus on fundamentals and compliance so find things that are going to get you to eat healthier, get you to sleep better and more regularly, get you to exercise more and so on. So an example of that, I have found it to be incredible to get me to stop drinking alcohol and to get me to be more regular with my sleep. And also for calorie goals, like, ill check it each day and be like, I havent crossed the 3000 calories for a, thats okay, because as long as Im hitting three calories, 3000 calories for the week, then Im on track.

Chris Mirabile
But ill track that because I always want to be above 3000 calories on average over a week or a month timeframe for those three, alcohol, regular sleep and being physically active. The oura ring has actually been a fantastic investment. Even if the accuracy or precision that sometimes can be questionable, the fact that it is, it is habit for me is ultimately what's important. And so I think it's important for people to think about that. What are the things that are going to get you to follow the healthy lifestyle?

These fundamental pillars that I mentioned and, you know, these really crazy exotic things or like, you know, go to get the cryotherapies and so on. Like, only worry about that once you've like, laid the foundation, 90% of the foundation. And then if you want to like be at the 99 and you want to be like Cristiano Ronaldo at the top of his game or something, like, all right, fine, then maybe experiment with that stuff, but that's not going to handle the foundation for you. Yeah, I love that so much. So do you doing all those things that you're doing, health, do you feel that much better?

Jenny Jones
Like, do you feel optimally, like, do you ever drink too? Like, do you do anything that kind of counteracts maybe the health and have a little balance or, and then, like, how that's my tat from why I love this space is because I've been lethargic. I couldn't breathe. Now I have great oxygen level, you know, like these things that I have gone from, like feeling awful to feeling amazing mentally and physically. So that's why my inspiration for this, because a lot of people are struggling and I think the mental is also a huge impact.

Like, you feel mentally drained, you feel mentally exhausted, you feel depressed, you feel like it's 03:00. I'm exhausted, you know, and that's right, like, you don't ever. Do you ever feel that anymore? Do you feel pretty energized all throughout the day and feel like. In my last five years, I've never felt better than I have in my last five years and back to my teens and my twenties.

Chris Mirabile
In fact, I just turned 40 a few weeks ago, and my goal was to run the fastest mile I have in my life. And I used to run track back in high school and 400 meters, 800 meters. And my fastest mile time was low five minute range. And just a couple of weeks ago, I ran just over a five minute 32nd mile. I'm very close to the fastest mile I've ever run in my life, and I'm 40 years old, right?

Like, I wouldn't be able to do that unless I got to this, you know, point of. Of really optimizing my biology. And what I think is really important is for people to realize that the longevity mindset and this longevity focused approach that we take at Novos, focusing on these hallmarks of aging, isnt only going to pay dividends in the long term to slow down your aging. Its optimizing your biology today, because these hallmarks of aging are fundamental to our health overall. Not just aging.

These are things that go wrong with aging, but optimal place, like mitochondrial function and so on. You're going to be able to produce the energy that you need to be able to outperform, uh, the weaker version of yourself. My physical performance, mental performance, focus. I can work for 12 hours straight and just, you know, uh, take a 30 minutes break for lunch, and I'm even working during that 30 minutes break, and I don't feel burnt out, I don't feel exhausted. I focus that entire time.

Jenny Jones
Definitely affect your dopamine, your serotonin, and everything. So that's why it's like this space. I just. It's so important for people to realize it's feel good now and also be preventative, you know, and extend your longevity. Yes, and I do.

Chris Mirabile
Questions? You know, I'm a lot more careful with the alcohol than I had been in my twenties and early thirties living in New York. But, you know, on special occasions, I'll indulge. But I'm not drinking to get drunk. I'm drinking thing to enjoy the experience, to enjoy the flavor of the wine or the scotch or something.

And I'll try to do it earlier in the evening so it's not close to my bedtime, because it really does impact my sleep. But then, more regularly than which, maybe I'll have alcohol like once a month or something I'm having. I'll treat myself on the weekends like a bowl of pasta or a dessert or something. The only thing is that if I am going to indulge like that, I make a point to have something healthy. Having the bowl of pasta, I'll get a side of spinach or broccolini.

If I'm having dessert, I'll make sure that it's only after having had, like, a nutritious meal before. Exactly. So I'll balance it out. So it's not as someone who's just only indulging in, like, a cheesecake factory cheesecake or something. Don't even say that.

Jenny Jones
There's one across the street from me and Marina. And I'm like, I don't even know. But people always like holding with the cheesecake factory. I'm like, I didn't even know that's there. Yeah, that's a good thing.

Yeah, I know. I'm like, I would never. But anyways, this was so great. I could go on and on. I know you're probably.

You have to travel. I'll be in London, too. I'm really excited for the health health optimization summit. I'm loving everything you guys do doing with Novo. So you're saying it's also going to keep expanding, right?

You guys are going to keep diving in? Not just the supplement, also the biotech. Oh, yeah. So, for example, we just launched yesterday. We've released the press release and got some press coverage for our free mobile app.

Chris Mirabile
So we're a public benefit corporation. We want to do as much as we can for the everyday person anywhere in the world to slow down their aging, even if they don't buy our products. And so we have an app that we just launched on iOS and Android called Novos Life. It includes a free biological age test in it, based, but it's actually more accurate than most of the epigenetic, blood based, and saliva based tests out on the market because it's more accurate than the first generation tests. And most companies are selling first generation tests.

Wow. I was trained on a data set of about 60,000 people, and we're able to tell you after you answer about 20 questions, how old you likely are biologically. And then we also give you a lifestyle score so we can tell tuned your lifestyle is to longevity, and then daily, daily recommendations for you to, like, make tweaks to your lifestyle. These are daily actionable steps that you can take. And then finally, we have a chatbot GPT type of chatbot, but it's been trained by our data set and our information so that you can ask it questions related to longevity.

So we're looking at this as being a tool for you to be able to understand what your biological then get the tips that you need to be able to improve that score and then have a partner to ask the AI questions to help you essentially accomplish those goals. Wow. Okay. I'm glad you free because I had no idea. That's amazing.

Jenny Jones
Well, congrats. That's so helpful for people. And I think that's so important because there's so much data out there and there's so many testing, but it's like, what do you do with that information as well, you know? So it's like it's good to have here's, and then here's some actionable items, you know, I think that's so important. Exactly, exactly.

Chris Mirabile
Yeah. So that's the first thing. And then we also have face age, which your customers, or, sorry, your listeners might be interested in. Face ages, facial. You can take a selfie and it will tell you how young you look and then different facial health markers, facial inflammation, wrinkles, pore size, deformity and so on.

And they give you actionable steps to improve those scores. A warning is this is, this is AI. So it is very objective and it gives you exactly how old or your perceived age is. If you're going to do it, make sure you have good front facing lighting. You don't want overhead lighting that under your eyes.

You want to make sure you're well hydrated. And then take, take the selfie and you'll get these scores and results. And it's actually closely correlated with your biological age as well as you can imagine. Now, some women do it with makeup on, and I wouldn't say that's going to be the most accurate output. To each their own, I guess.

Jenny Jones
Yeah. Okay, well, everyone can go and try that out as they wish, or maybe they don't want to. Okay, well, typing biohacker blondie podcast, I just want to ask my guests, three biohacks. You want to share your favorite biohacks that you would love to tell the audience?

Chris Mirabile
Okay, well, I'd say about them, yeah, I like to keep it relatively, yeah, relatively simple that the things that we know are going to improve our health. So that's improving our sleep. And so I would say, you know, earplugs, super cheap hack take costs you a dollar or so for a set of earplugs. And the sleep, amazing. The hue light bulbs, those are a little bit get cheaper alternatives on Amazon, but like changing the color, the temperature of your lights in the evening, it also can serve as a signal to you if you automate it like every night at say 10:00 p.m.

automatically changes to red. That's going to trigger you to be like, oh, let me, let me start to calm down and stop being absorbed in everything else. And it can start this whole routine for you to improve your sleep. And then, of course, I would say yes. The Novos Novoscore, which is the staple that's the foundation of our product line, it has the most research behind it.

We didn't really go into the research, but your audience can check out novoslabs.com and then go to the science section and you can see the proof points that we have, the scientific studies that have been run with our formula. It looks at DNA damage, cellular senescence, oxytocin, reducing biological pace of aging epigenetically for the vast majority of use, our product, and so on. So there's a lot of evidence that is accumulating in favor of our formula. I love that so much. So.

Jenny Jones
Well, thank you so much for coming on the podcast. This is great. I learned so much. I know the audience learned. So thank you so much for taking the time out of your day.

I really appreciate it. Thank you, Jim. Thank you for tuning in to this episode of the Biohacker Bondi podcast. I hope you found our conversation from Novos Labs and insightful and inspiring, as I did. Chris's dedication to understanding the science of aging and optimizing health through practical lifestyle choices and innovative products is truly remarkable.

Remember, you can check out Novos product line, including the groundbreaking Novos core. And don't forget to explore the new new Novos live mobile app for your free biological age test and daily health recommendations. If you enjoyed this episode, please subscribe. Leave a review who might benefit from these insights. Your support helps me continue bringing you the latest in health optimization and biohacking.

Stay tuned for more exciting episodes, and as always, keep hacking your way to a healthier, happier life. I'm Ginny Jones, your biohacker. Blondie, signing off. Stay healthy, stay vibrant, and keep biohacking.